Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/1086
Título: Behaviour of human erythrocyte aggregation in presence of autologous lipoproteins
Autor: Saldanha, C
Loureiro, J
Moreira, C
Silva, J
Palavras-chave: Erythrocyte aggregation
Agregação eritrocítica
Lipoproteins
Lipoproteínas
Data: 2012
Editora: Hindawi Pub
Citação: Biochem Res Int. 2012;2012:261736. doi: 10.1155/2012/261736.
Resumo: The aim of this work was to evaluate in vitro the effect of autologous plasma lipoprotein subfractions on erythrocyte tendency to aggregate. Aliquots of human blood samples were enriched or not (control) with their own HDL-C, LDL-C, or VLDL-C fractions obtained from the same batch by density gradient ultracentrifugation. Plasma osmolality and erythrocyte aggregation index (EAI) were determined. Blood aliquots enriched with LDL-C and HDL-C showed significant higher EAI than untreated aliquots, whereas enrichment with VLDL-C does not induce significant EAI changes. For the same range of lipoprotein concentrations expressed as percentage of osmolality variation, the EAI variation was positive and higher in presence of HDL-C than upon enrichment with LDL-C (P < 0.01). Particle size, up to LDL diameter values, seems to reinforce erythrocyte tendency to aggregate at the same plasma osmolality (particle number) range of values.
Peer review: yes
URI: http://hdl.handle.net/10400.10/1086
ISSN: 2090-2255
Versão do Editor: http://www.hindawi.com/journals/bri/2012/261736/
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