Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/1416
Título: An 18-year-old woman with a 34-cm metaplastic breast carcinoma
Autor: Gomes, A
Santos, V
Dias, G
Manso, R
Gonçalves, L
Coiteiro, M
Gaspar, H
Nazaré, A
Palavras-chave: Breast neoplasms
Mastectomy
Prognosis
Data: 2015
Editora: Oxford University Press
Citação: J Surg Case Rep. 2015 Jan;1: 1-4
Resumo: Metaplastic breast carcinomas (MBCs) are rare malignancies usually with poor prognosis. We report a case of an 18-year-old African female patient who presented with a 34-cm tumor on the right breast. Biopsy showed an extensively necrotic MBC negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (triple negative). A modified right radical mastectomy was performed, followed by adjuvant chemotherapy. Histology confirmed a widely necrotic undifferentiated malignant tumor, with strong and diffuse expression of vimentin and B-cell lymphoma 2, focal high-molecular-weight keratins and focal CD34 expression; Ki67 was >90%. There was no skin, deep margin or lymph node involvement. Six months after surgery, the patient showed a 9 × 7 cm nodule adjacent to the suture and adherent to the anterior chest wall. The tumor was considered unresectable and the patient evolved with rapid systemic deterioration. The patient had a progression-free survival of 6 months and overall survival of 9 months.
Peer review: yes
URI: http://hdl.handle.net/10400.10/1416
DOI: 10.1093/jscr/rju141.
Versão do Editor: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294453/pdf/rju141.pdf
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