Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/1993
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dc.contributor.authorPaiva-Lopes, MJ-
dc.contributor.authorAlves, J-
dc.date.accessioned2018-04-16T14:20:53Z-
dc.date.available2018-04-16T14:20:53Z-
dc.date.issued2017-
dc.identifier.citationJ Biomed Sci. 2017 Sep 14;24(1)pt_PT
dc.identifier.issn1423-0127-
dc.identifier.urihttp://hdl.handle.net/10400.10/1993-
dc.description.abstractPsoriasis is a chronic inflammatory systemic disease with a prevalence of 2-3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiovascular disease is the most frequent cause of death in patients with severe psoriasis. Several cardiovascular disease classical risk factors are also increased in psoriasis but the psoriasis-associated risk persists after adjusting for other risk factors.Investigation has focused on finding explanations for these epidemiological data. Several studies have demonstrated significant lipid metabolism and HDL composition and function alterations in psoriatic patients. Altered HDL function is clearly one of the mechanisms involved, as these particles are of the utmost importance in atherosclerosis defense. Recent data indicate that biologic therapy can reverse both structural and functional HDL alterations in psoriasis, reinforcing their therapeutic potential.pt_PT
dc.language.isoengpt_PT
dc.publisherBioMed Centralpt_PT
dc.rightsopenAccesspt_PT
dc.subjectCardiovascular diseasespt_PT
dc.subjectPsoriasispt_PT
dc.subjectHDL lipoproteinspt_PT
dc.titlePsoriasis-associated vascular disease: the role of HDL.pt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.locationLondonpt_PT
degois.publication.titleJournal of Biomedical Sciencept_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598036/pdf/12929_2017_Article_382.pdfpt_PT
dc.peerreviewedyespt_PT
dc.identifier.doi10.1186/s12929-017-0382-4pt_PT
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