Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/649
Título: Examining the motor phenotype of patients with both essential tremor and Parkinson's disease.
Autor: Simões, R
Constantino, A
Gibadullina, E
Houghton, D
Louis, E
Litvan, I
Palavras-chave: Doença de Parkinson
Tremor
Avaliação da incapacidade
Parkinson’s disease
Essential tremor
Severity of illness index
Data: 2012
Editora: Center for Digital Research and Scholarship
Citação: Tremor Other Hyperkinet Mov (N Y). 2012;2. pii: 47
Resumo: Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor-predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor-dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD.
Peer review: yes
URI: http://hdl.handle.net/10400.10/649
ISSN: 2160-8288
Versão do Editor: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379814/?tool=pubmed
Aparece nas colecções:NEU - Artigos

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