Repository logo
 
Publication

Decreased Survival in African Patients with Triple Negative Breast Cancer

dc.contributor.authorHonório, M
dc.contributor.authorGuerra-Pereira, N
dc.contributor.authorSilva, J
dc.contributor.authorAlves, J
dc.contributor.authorFilipa, A
dc.contributor.authorBraga, S
dc.date.accessioned2019-12-23T15:57:07Z
dc.date.accessioned2019-12-23T15:57:10Z
dc.date.available2019-12-23T15:57:07Z
dc.date.available2019-12-23T15:57:10Z
dc.date.issued2016
dc.description.abstractAbstract Introduction: Triple Negative Breast Carcinomas (TNBC) are more prevalent in younger women especially those with African Ancestry, in whom the disease appears to be more aggressive. Since there are no data on Africans living in continental Europe, we sought to analyse a sample of African women from a European country and determine if, like African Americans, they have more aggressive tumor biology and poorer outcomes. Methods: We performed a retrospective review of TNBC to compare clinical and pathological features and survival between African and non-African patients. All women presented with breast cancer (BC), between 2005 and 2014, to a single general hospital, in Portugal. Results: A total of 144 (9.3% of the whole sample) TNBC patients were identified and amongst these, 17 were African (12%). African patients were not significantly younger than non-African patients (median age of 60 years vs 57.2 years, respectively, p=0.59). Regarding tumor size, nodal status and histologic grade at presentation, these variables were very similar between the two cohorts. Nevertheless, the prevalence of initially metastatic BC was significantly higher among the African population (41.2% vs 11%, p<0,005) and the outcome was worse for these patients (median survival: 62 vs 15 months, p<0.005). Conclusions: Our study demonstrated that African patients more frequently presented with late stage disease and worse survival outcome than the non-African population. These findings may be explained by more aggressive tumor biology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Palliat Care Med 2016, 6:4pt_PT
dc.identifier.doi10.4172/2165-7386.1000270pt_PT
dc.identifier.issn2165-7386
dc.identifier.urihttp://hdl.handle.net/10400.10/2378
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOMICS Internationalpt_PT
dc.relation.publisherversionfile:///U:/Downloads/decreased-survival-in-african-patients-with-triple-negative-breast-cancer-2165-7386-1000270.pdfpt_PT
dc.subjectBreast neoplasmspt_PT
dc.titleDecreased Survival in African Patients with Triple Negative Breast Cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of palliative care & medicinept_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
J Palliat Care Med 2016.pdf
Size:
470.96 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: