Publication
A Rare Case of Bilateral Proptosis
| dc.contributor.author | Serodio, J | |
| dc.contributor.author | Jonet, M | |
| dc.contributor.author | Trinidade, M | |
| dc.contributor.author | Coutinho, I | |
| dc.contributor.author | Favas, C | |
| dc.date.accessioned | 2019-03-08T15:55:50Z | |
| dc.date.available | 2019-03-08T15:55:50Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | A 65-year-old man presented with a 2-year history of severe bilateral proptosis, palpable lymphadenopathy and moderate hepatosplenomegaly. A blood test was positive for hepatitis C infection. CT showed palpebral infiltrative lesions with regional progression through the temporal and masticatory spaces to the pharynx and hypopharynx causing almost complete airway obstruction. A palpebral biopsy was consistent with low-grade Bcl-2+ extra-nodal MALT non-Hodgkin B-cell lymphoma. The patient received six cycles of rituximab-based chemotherapy with clinical remission at 9-month follow-up. Bilateral proptosis is a rare presentation of several diseases. When brain CT excludes cavernous sinus pathology, thyroid ophthalmopathy or haematological malignancy should be considered. LEARNING POINTS: Bilateral proptosis is a rare presentation with a broad differential diagnosis, and is most frequently is caused by cavernous sinus disease, thyroid ophthalmopathy or haematological malignancy.Hepatitis C may be associated with MALT lymphoma and presents mainly at non-gastric locations even with few hepatic manifestations of the infection.Long-term low-grade lymphoma may present with severe disseminated disease at diagnosis, but treatment response is generally good. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Eur J Case Rep Intern Med. 2018 Nov 28;5(11):000966 | pt_PT |
| dc.identifier.doi | 10.12890/2018_000966 | pt_PT |
| dc.identifier.issn | 2284-2594 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2153 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | SMC Media | pt_PT |
| dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346810/pdf/966-1-6179-1-10-20181026.pdf | pt_PT |
| dc.subject | Marginal zone B-cell lymphoma | pt_PT |
| dc.subject | Hepatitis C | pt_PT |
| dc.title | A Rare Case of Bilateral Proptosis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Milano | pt_PT |
| oaire.citation.title | European Journal of Case Reports in Internal Medicine | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |