Publication
Off-Label Use of Ultrasound Contrast Agents for Intravenous Applications in Children: Analysis of the Existing Literature
| dc.contributor.author | Rosado, E | |
| dc.contributor.author | Riccabona, M | |
| dc.date.accessioned | 2017-03-13T16:34:45Z | |
| dc.date.available | 2017-03-13T16:34:45Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | OBJECTIVES: The purpose of this study was to collect and analyze the published data related to intravenous (IV) use of ultrasound (US) contrast agents in children. METHODS: We searched the literature to collect all of the published studies reporting the IV administration of a second-generation US contrast agent in children. RESULTS: We analyzed 9 case series and 5 case reports, as well as 5 individual cases, of pediatric contrast-enhanced US use reported in a study group that also included adults. We found that 502 children underwent contrast-enhanced US examinations (mean age, 9.7 years; range, 1 day-18 years). Most patients (89%) were injected with the sulfur hexafluoride contrast agent SonoVue (Bracco SpA, Milan, Italy). The mean dose used was 1.5 mL (range, 0.1-9.6 mL). Only 10 patients (2%) had adverse reactions related to the contrast agent administration: 1 life-threatening anaphylactic shock and 9 mild transitory adverse effects. We additionally found 38 papers in which the study groups included at least 1 child; thus, we obtained a total of 540 reported cases of off-label use of IV US contrast agents in children. The most frequent target organ was the liver, and most indications were related to space-occupying lesion characterization and abdominal evaluations after blunt trauma. Some studies also evaluated the diagnostic performance of contrast-enhanced US in different clinical scenarios and found very good accuracy. Concordance between contrast-enhanced US imaging and the respective reference-standard imaging methods ranged between 83% and 100% in different studies. CONCLUSIONS: Our results support the idea that the IV use of US contrast agents in children is safe, feasible, diagnostically robust, and effective. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Ultrasound Med. 2016 Mar;35(3):487-96 | pt_PT |
| dc.identifier.doi | 10.7863/ultra.15.02030 | pt_PT |
| dc.identifier.issn | 1550-9613 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/1825 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | John Wiley and Sons | pt_PT |
| dc.subject | Contrast media | pt_PT |
| dc.subject | Drug-Related Side Effects and Adverse Reactions | pt_PT |
| dc.subject | Ultrasonography | pt_PT |
| dc.subject | Reacções adversas a medicamentos | pt_PT |
| dc.subject | Meios de contraste | pt_PT |
| dc.subject | Ultrassonografia | pt_PT |
| dc.title | Off-Label Use of Ultrasound Contrast Agents for Intravenous Applications in Children: Analysis of the Existing Literature | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Oxford | pt_PT |
| oaire.citation.endPage | 496 | pt_PT |
| oaire.citation.startPage | 487 | pt_PT |
| oaire.citation.title | Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine | pt_PT |
| oaire.citation.volume | 35 | pt_PT |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |