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Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study.

2016Journal article Open access
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dc.contributor.authorAmengual, O
dc.contributor.authorForastiero R, R
dc.contributor.authorSugiura-Ogasawara, M
dc.contributor.authorOtomo, K
dc.contributor.authorOku, K
dc.contributor.authorFavas, C
dc.contributor.authorAlves, JD
dc.contributor.authorŽigon, P
dc.contributor.authorAmbrožič, A
dc.contributor.authorTomšič, M
dc.contributor.authorRuiz-Arruza, I
dc.contributor.authorRuiz-Irastorza, G
dc.contributor.authorBertolaccini, ML
dc.contributor.authorNorman, GL
dc.contributor.authorShums, Z
dc.contributor.authorArai, J
dc.contributor.authorMurashima, A
dc.contributor.authorTebo, AE
dc.contributor.authorGerosa, M
dc.contributor.authorMeroni, PL
dc.contributor.authorRodriguez-Pintó, I
dc.contributor.authorCervera, R
dc.contributor.authorSwadzba, J
dc.contributor.authorMusial, J
dc.contributor.authorAtsumi, T
dc.date.accessioned2017-01-10T14:43:58Z
dc.date.available2017-01-10T14:43:58Z
dc.date.issued2016
dc.description.abstractOBJECTIVE: A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted to ascertain the value of aPS/PT for APS diagnosis. METHODS: In the initial study (eight centres, seven countries), clinical/laboratory data were retrospectively collected. Serum/plasma samples were tested for IgG aPS/PT at Inova Diagnostics (Inova) using two ELISA kits. A replication study (five centres, five countries) was carried out afterwards. RESULTS: In the initial study (n = 247), a moderate agreement between the IgG aPS/PT Inova and MBL ELISA kits was observed (k = 0.598). IgG aPS/PT were more prevalent in APS patients (51%) than in those without (9%), OR 10.8, 95% CI (4.0-29.3), p < 0.0001. Sensitivity, specificity, positive (LR+) and negative (LR-) likelihood ratio of IgG aPS/PT for APS diagnosis were 51%, 91%, 5.9 and 0.5, respectively. In the replication study (n = 214), a moderate/substantial agreement between the IgG aPS/PT results obtained with both ELISA kits was observed (k = 0.630). IgG aPS/PT were more prevalent in APS patients (47%) than in those without (12%), OR 6.4, 95% CI (2.6-16), p < 0.0001. Sensitivity, specificity, LR + and LR- for APS diagnosis were 47%, 88%, 3.9 and 0.6, respectively. CONCLUSIONS: IgG aPS/PT detection is an easily performed laboratory parameter that might contribute to a better and more complete identification of patients with APS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLupus. 2016 Aug 10. pii: 0961203316660203. [Epub ahead of print]pt_PT
dc.identifier.doi10.1177/0961203316660203pt_PT
dc.identifier.issn1477-0962
dc.identifier.urihttp://hdl.handle.net/10400.10/1785
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttp://journals.sagepub.com/doi/pdf/10.1177/0961203316660203pt_PT
dc.subjectSystemic lupus erythematosuspt_PT
dc.subjectAntiphospholipid syndromept_PT
dc.subjectThrombosispt_PT
dc.subjectLúpus eritematoso sistémicopt_PT
dc.titleEvaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.titleLupuspt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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