Publication
Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study.
| dc.contributor.author | Serrão, R | |
| dc.contributor.author | Piñero, C | |
| dc.contributor.author | Velez, J | |
| dc.contributor.author | Coutinho, D | |
| dc.contributor.author | Maltez, F | |
| dc.contributor.author | Lino, S | |
| dc.contributor.author | Sarmento, E | |
| dc.contributor.author | Castro, R | |
| dc.contributor.author | Tavares, AP | |
| dc.contributor.author | Pacheco, P | |
| dc.contributor.author | Lopes, MJ | |
| dc.contributor.author | Mansinho, K | |
| dc.contributor.author | Miranda, AC | |
| dc.contributor.author | Neves, I | |
| dc.contributor.author | Abreu, R | |
| dc.contributor.author | Almeida, J | |
| dc.contributor.author | Pássaro, L | |
| dc.date.accessioned | 2019-01-21T15:50:51Z | |
| dc.date.available | 2019-01-21T15:50:51Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | OBJECTIVE: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. METHODS: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. RESULTS: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). CONCLUSIONS: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Int J Infect Dis. 2018 Oct 25;79:94-100. | pt_PT |
| dc.identifier.doi | 10.1016/j.ijid.2018.10.011 | pt_PT |
| dc.identifier.issn | 1878-3511 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2078 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://www.clinicalkey.com/service/content/pdf/watermarked/1-s2.0-S1201971218345570.pdf?locale=pt_BR | pt_PT |
| dc.subject | HIV infections | pt_PT |
| dc.subject | HIV-1 | pt_PT |
| dc.subject | Aging | pt_PT |
| dc.title | Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study. | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Hamilton, ON | pt_PT |
| oaire.citation.endPage | 100 | pt_PT |
| oaire.citation.startPage | 94 | pt_PT |
| oaire.citation.title | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. | pt_PT |
| oaire.citation.volume | 79 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |