Publication
Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer.
| dc.contributor.author | Tereso, A | |
| dc.contributor.author | Carreto, L | |
| dc.contributor.author | Baptista, M | |
| dc.contributor.author | Almeida, MA | |
| dc.date.accessioned | 2019-05-07T13:27:36Z | |
| dc.date.available | 2019-05-07T13:27:36Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | The treatment of advanced non-small-cell lung cancer shifted with the development of molecular-targeted therapies, like the tyrosine kinase inhibitors. One example of tyrosine kinase inhibitors is crizotinib, an anaplastic lymphoma tyrosine kinase inhibitor, which targets an echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase gene fusion. This mutation is found in only 2% to 7% of non-small-cell lung cancer cases. Although these new therapies have shown promising results, the occurrence of interstitial lung disease as a side effect could be problematic. As the diagnosis of drug-related-interstitial lung disease is difficult to make, computed tomography is an important diagnostic tool. The recognition of computed tomography manifestations of tyrosine kinase inhibitors -induced interstitial lung disease is the key for an early recognition and management of this pulmonary toxicity. We aim to raise awareness of tyrosine kinase inhibitors-induced interstitial lung disease, by reporting the first case of a Portuguese patient treated with crizotinib for non-small-cell lung cancer who developed drug-induced interstitial lung disease. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Acta Med Port. 2019 Mar 29;32(3):236-239 | pt_PT |
| dc.identifier.doi | 10.20344/amp.9456 | pt_PT |
| dc.identifier.issn | 1646-0758 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2228 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Ordem dos Médicos | pt_PT |
| dc.relation.publisherversion | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9456/5638 | pt_PT |
| dc.subject | Lung neoplasms | pt_PT |
| dc.subject | Non-small-cell lung cancer | pt_PT |
| dc.subject | Crizotinib | pt_PT |
| dc.title | Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer. | pt_PT |
| dc.title.alternative | Doença Pulmonar Intersticial Associada ao Crizotinib no Tratamento de Cancro do Pulmão de Não Pequenas Células | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa | pt_PT |
| oaire.citation.title | Acta Médica Portuguesa | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |