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Hemophagocytic lymphohistiocytosis, Leishmania and Epstein-Barr infection: an uncommon association

2018Journal article Open access
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dc.contributor.authorCosta, F
dc.contributor.authorMiranda, A
dc.contributor.authorFigueiredo, A
dc.contributor.authorCorreia, P
dc.date.accessioned2020-07-16T10:02:32Z
dc.date.available2020-07-16T10:02:32Z
dc.date.issued2018
dc.description.abstractIntroduction: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of abnormal excessive immune activation, with signs and symptoms of excessive inflammation. Case report: 18-months-old girl admitted for persistent fever for the past two months. No other symptoms associated. History of a trip to the north of Portugal with contact with dogs. On examination: ill-appearance, pale and hepatosplenomegaly. Laboratory findings revealed pancytopenia progressively worst, associated with elevated ferritin (828ng/mL), hypertriglyceridemia (490 mg/dL), elevated soluble interleukin-2-receptor (11045 U/mL), which lead to the diagnosis of HLH. Etiologic investigation: IgM VCA-EBV positive (99U/mL), IgG VCA-EBV negative (<20U/mL), IgG EBNA negative (<3U/mL) and PCR for EBV negative; immunofluorescence and immunoblot serologies for Leishmania spp. were positive. Bone marrow examination did not reveal hemophagocytosis and PCR for Leishmania and EBV was negative. Treatment was initiated with lipossomic amphotericin with progressive improvement of the clinical condition. Discussion: Although serology for Leishmania is not the gold standard for diagnosis, it’s positivity in this case and the epidemiologic history lead to a favourable outcome.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRevista SPDV. 2018; 14(3): 106-110pt_PT
dc.identifier.issn2182-2409
dc.identifier.urihttp://hdl.handle.net/10400.10/2483
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Dermatologia e Venereologiapt_PT
dc.relation.publisherversionhttp://spdimc.org/wp/wp-content/uploads/2019/04/RPDI_14-3.pdfpt_PT
dc.subjectFever of unknown originpt_PT
dc.subjectLeishmaniasispt_PT
dc.subjectHemophagocytic lymphohistiocytosispt_PT
dc.titleHemophagocytic lymphohistiocytosis, Leishmania and Epstein-Barr infection: an uncommon associationpt_PT
dc.title.alternativeLinfohistiocistose hemofagocítica, infeção por Leishmania e Epstein-Barr: uma associação incomumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
oaire.citation.titleRevista da Sociedade Portuguesa de Dermatologia e Venereologiapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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