Publication
Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy.
| dc.contributor.author | Portela, F | |
| dc.contributor.author | Ministro, P | |
| dc.contributor.author | Deus, JR | |
| dc.contributor.author | Cravo, M | |
| dc.contributor.author | Cotter, J | |
| dc.contributor.author | Duque, G, e outros | |
| dc.date.accessioned | 2019-10-28T17:05:03Z | |
| dc.date.available | 2019-10-28T17:05:03Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | PURPOSE: Ulcerative colitis (UC) can be managed with immunomodulation or surgery. We aimed to understand whether these strategies had a different impact on patients' health-related quality of life (HRQoL). METHODS: This was a retrospective, cross-sectional study: patients who had a moderate to severe UC episode that prompted the utilization of immunomodulatory drugs or surgery were invited to complete a generic (short form [36] health survey [SF-36]) and a disease-specific (inflammatory bowel disease questionnaire [IBDQ]) survey. RESULTS: We included 157 patients, 65 (41.4%) surgically treated. The therapeutic procedure had a minimal impact on HRQoL: only the social dimension of the IBDQ and the physical function component of the SF-36 were significantly different between the study arms - lower for the surgically treated patients. The type of surgery had no impact, but the occurrence of pouchitis, namely, in a chronic form, was associated with a lower HRQoL. Regression analysis confirmed surgery as an independent predictor of lower scores in the social dimension of the IBDQ (-4.646, 95% CI -6.953 to -2.339) and in the physical functioning (-9.622, 95% CI -17.061 to -2.183) and physical role functioning (-3.669, 95% CI -7.339 to 0.001) dimensions of the SF36. CONCLUSIONS: Although usually feared by patients, surgery has a limited impact on UC patients HRQoL when compared to medical management with immunomodulatory drugs. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Digestion. 2019 Sep 6:1-7. | pt_PT |
| dc.identifier.doi | 10.1159/000501823 | pt_PT |
| dc.identifier.issn | 1421-9867 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2316 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Karger Publishers | pt_PT |
| dc.subject | Quality of life | pt_PT |
| dc.subject | Ulcerative colitis | pt_PT |
| dc.title | Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy. | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Basel | pt_PT |
| oaire.citation.title | Digestion | pt_PT |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |