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Endothelial dysfunction evaluated by peripheral arterial tonometry is related with peak TnI values in patients with ST elevation myocardial infarction treated with primary angioplasty

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dc.contributor.authorBaptista, SB
dc.contributor.authorFaustino, M
dc.contributor.authorSimões, J
dc.contributor.authorNédio, M
dc.contributor.authorMonteiro, C
dc.contributor.authorLourenço, E
dc.contributor.authorLeal, P
dc.contributor.authorAbreu, PF
dc.contributor.authorGil, V
dc.date.accessioned2016-12-29T14:29:24Z
dc.date.available2016-12-29T14:29:24Z
dc.date.issued2016
dc.description.abstractPURPOSE: The role of endothelial-dependent function in patients with acute ST elevation myocardial infarction (STEMI) is not clear. Endothelial dysfunction may contribute to the pathophysiological processes occurring after STEMI and influence the extension of myocardial necrosis. Endothelial-dependent dysfunction evaluated by peripheral arterial tonometry (PAT) has already showed to be correlated with microvascular coronary endothelial dysfunction. Our purpose was to evaluate the impact of endothelial dysfunction on peak Troponin I (TnI) values, as a surrogate for the extension of myocardial infarction, in patients with STEMI treated with primary angioplasty (P-PCI). METHODS: 58 patients with STEMI treated with P-PCI (mean age 59.0 ± 14.0 years, 46 males) were included. Endothelial function was assessed by reactive hyperaemia index (RHI) determined by PAT. Patients were divided in two groups according to the previously reported RHI threshold for high risk (1.67). The extension of myocardial necrosis was evaluated by peak TnI levels. RESULTS: RHI median value was 1.78 (IQR0.74);25 patients had endothelial dysfunction (RHI b 1.67). The two groups had no significant differences in age, gender, main risk factors and pain-to-balloon time. Patients with an RHI b 1.67 had significant larger infarcts: TnI 73.5 ng/mL (IQR 114.42 ng/mL) versus TnI 33.2 ng/mL (IQR 65.2 ng/mL); p = 0.028. On multivariate analysis, the presence of an RHI b 1.67 kept significant impact on TnI peak values (p=0.02). CONCLUSIONS: The presence of endothelial-dependent dysfunction, assessed by PAT, is related with higher peak TnI values in STEMI patients treated with P-PCI. These results strength the possibility that endothelial-dependent dysfunction may be a marker of poor prognosis and eventually a therapeutic target in patients with STEMI.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMicrovasc Res. 2016 May;105:34-9pt_PT
dc.identifier.doi10.1016/j.mvr.2015.12.010pt_PT
dc.identifier.issn1095-9319
dc.identifier.urihttp://hdl.handle.net/10400.10/1780
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAcademic Presspt_PT
dc.subjectMyocardial infarctionpt_PT
dc.subjectAngioplastypt_PT
dc.subjectBiomarkerspt_PT
dc.subjectEnfarte do miocárdiopt_PT
dc.titleEndothelial dysfunction evaluated by peripheral arterial tonometry is related with peak TnI values in patients with ST elevation myocardial infarction treated with primary angioplastypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Yorkpt_PT
oaire.citation.endPage39pt_PT
oaire.citation.startPage34pt_PT
oaire.citation.titleMicrovascular Researchpt_PT
oaire.citation.volume105pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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