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Outcomes of Trabeculectomy With and Without Mitomycin C in Pseudoexfoliative Glaucoma Compared With Mitomycin C in Primary Open Angle Glaucoma.

dc.contributor.authorLopes, AS
dc.contributor.authorVaz, F
dc.contributor.authorHenriques, S
dc.contributor.authorLisboa, M
dc.contributor.authorVendrell, C
dc.contributor.authorPrieto, I
dc.date.accessioned2019-12-17T12:26:47Z
dc.date.available2019-12-17T12:26:47Z
dc.date.issued2019
dc.description.abstractThe aim of this study was to evaluate the outcomes of trabeculectomy with mitomycin C (MMC) in patients with Pseudoexfoliative Glaucoma (PXG) and compare the results with the outcomes of trabeculectomy without MMC in PXG and with MMC in Primary Open Angle Glaucoma (POAG). Ninety eyes (76 patients) submitted to trabeculectomy were included in a one-year retrospective study. Fifty-eight eyes with PXG were divided into group 1 (28 eyes) and group 2 (30 eyes), with and without MMC application respectively. Then, the group 1 results were compared with 32 eyes with POAG that performed trabeculectomy with MMC (group 3). Main outcome measures were intraocular pressure (IOP), number of IOP lowering medications, rate of bleb failure (encapsulation, flattening and/or vascularization) and the number of eyes submitted to surgical procedures after trabeculectomy (needling, 5-fluorouracil (5FU) or 2nd trabeculectomy). Results revealed that compared to trabeculectomy with MMC in POAG and trabeculectomy with MMC in PXG, trabeculectomy without MMC in PXG leads to higher IOP (preoperative mean ± standard deviation [SD] was 28.6 ± 5.4 mmHg in group 1, 32.2 ± 8.2 mmHg in group 2 and 26.1 ± 6.5 mmHg in group 3; and after one year was 13.9 ± 3.9 mmHg in group 1, 16.1 ± 5.9 mmHg in group 2 and 12.5 ± 4.0 mmHg in group 3); higher number of IOP lowering medications (preoperative mean ± SD was 3.1 ± 0.60 in group 1, 2.8 ± 0.81 in group 2 and 3.4 ± 0.76 in group 3; and after one year was 1.1 ± 1.1 in group 1, 1.1 ± 1.0 in group 2 and 0.33 ± 0.89 in group 3); higher prevalence of bleb failure (47% in group 1, 53% in group 2, and 18% in group 3); and increased participation in surgical procedures following trabeculectomy (47% in group 1, 57% in group 2, and 6% in group 3). We concluded that trabeculectomy without MMC in PXG had the worst surgical outcome. Thus, PXG appears to be a potential risk factor for filtration bleb failure. Therefore, it could be considered in surgical protocols of MMC application.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMed Hypothesis Discov Innov Ophthalmol. 2019 Summer;8(2):73-80.pt_PT
dc.identifier.issn2322-3219
dc.identifier.urihttp://hdl.handle.net/10400.10/2358
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInternational Virtual Ophthalmic Research Centerpt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592308/pdf/mehdiophth-8-073.pdfpt_PT
dc.subjectGlaucomapt_PT
dc.subjectSurgical Flapspt_PT
dc.subjectSurgical Flaps*pt_PT
dc.subjectTrabeculectomypt_PT
dc.titleOutcomes of Trabeculectomy With and Without Mitomycin C in Pseudoexfoliative Glaucoma Compared With Mitomycin C in Primary Open Angle Glaucoma.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceHoustonpt_PT
oaire.citation.titleMedical hypothesis, discovery and innovation ophthalmology journal.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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