Publication
Efficacy of Electroconvulsive Therapy in Bipolar Disorder with Mixed Features.
| dc.contributor.author | Palma, M | |
| dc.contributor.author | Ferreira, B | |
| dc.contributor.author | Borja-Santos, N | |
| dc.contributor.author | Trancas, B | |
| dc.contributor.author | Monteiro, C | |
| dc.contributor.author | Cardoso, G | |
| dc.date.accessioned | 2016-03-28T13:00:44Z | |
| dc.date.available | 2016-03-28T13:00:44Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | BACKGROUND: The aim of this study was to investigate the effectiveness of electroconvulsive therapy (ECT) in medication-nonresponsive patients with mixed mania and bipolar depression. METHOD: Forty-one patients with mixed mania (DSM-IV diagnosis of bipolar I disorder, most recent episode mixed) and 23 patients with bipolar depression (DSM-IV diagnosis of bipolar I disorder, most recent episode depressed) consecutively assigned to ECT treatment were included in this study. Subjects were evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions-Severity of Illness scale (CGI-S). Assessments were carried out the day before starting ECT, 48 hours after completion of the third session (T1), and a week after the last session of ECT (T2). RESULTS: Both groups received an equal number of ECT sessions (mean +/- SD = 7.2 +/- 1.7 vs. 7.3 +/- 1.6). In both groups, within-group comparisons showed that there was a significant reduction in CGI-S score (mixed mania, p <.0001 at T1 and T2; bipolar depression, p < .01 at T1, p < .0001 at T2), MADRS total score (both groups, p < .0001 at T1 and T2), BPRS total score (mixed mania, p < .0001 at T1 and T2; bipolar depression, p < .001 at T1, p < .0001 at T2), and BPRS activation factor score (mixed mania, p < .0001 at T1 and T2; bipolar depression, NS at T1, p < .01 at T2). Between-group comparisons revealed that patients with mixed mania showed significantly greater decrease in MADRS score (p < .001) and a greater proportion of responders (CGI-S) than patients with bipolar depression at endpoint (56% [N = 23] vs. 26% [N = 6], p = .02). Patients with mixed mania showed a greater reduction in suicidality, as measured by MADRS score, than patients with bipolar depression (p < .02). CONCLUSION: In our study, ECT was associated with a substantial reduction in symptomatology, in both patients with mixed mania and those with bipolar depression. However, the mixed mania group exhibited a more rapid and marked response as well as a greater reduction in suicidal ideation. Response to ECT was not influenced by the presence of delusions. | pt_PT |
| dc.identifier.citation | Depress Res Treat. 2016;2016:8306071 | pt_PT |
| dc.identifier.doi | 10.1155/2016/8306071 | pt_PT |
| dc.identifier.issn | 2090-133X | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/1588 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Hindawi Pub | pt_PT |
| dc.relation.publisherversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736372/ | pt_PT |
| dc.subject | Electroconvulsive therapy | pt_PT |
| dc.subject | Bipolar disorder | pt_PT |
| dc.subject | Terapêutica electroconvulsiva | pt_PT |
| dc.subject | Perturbação bipolar | pt_PT |
| dc.title | Efficacy of Electroconvulsive Therapy in Bipolar Disorder with Mixed Features. | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | New York | pt_PT |
| oaire.citation.title | Depression research and treatment | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |