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Dyschromatopsia in Multiple Sclerosis Patients: A Marker of Subclinical Involvement?

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dc.contributor.authorFelgueiras, H
dc.contributor.authorParra, J
dc.contributor.authorCruz, S
dc.contributor.authorPereira, P
dc.contributor.authorSantos, A
dc.contributor.authorRua, A
dc.contributor.authorMeira, D
dc.contributor.authorFonseca, P
dc.contributor.authorPedrosa, C
dc.contributor.authorCardoso, J
dc.contributor.authorAlmeida, C
dc.contributor.authorAraújo, M
dc.contributor.authorSantos, E
dc.date.accessioned2017-01-09T16:37:14Z
dc.date.available2017-01-09T16:37:14Z
dc.date.issued2016
dc.description.abstractBACKGROUND: In multiple sclerosis (MS), even in the absence of a clinical episode of optic neuritis (ON), the optic nerve and retinal nerve fiber layer (RNFL) may be damaged leading to dyschromatopsia. Subclinical dyschromatopsia has been described in MS associated with lower motor and cognitive performances. OBJECTIVES: To set the prevalence of dyschromatopsia in eyes of MS patients without a history of ON, to compare its prevalence in patients with and without ON history, and to explore the association between dyschromatopsia and disease duration, average peripapillary RNFL thickness, macular volume, and cognitive and motor performances. METHODS: An observational cross-sectional study was conducted at multiple medical centers. Data were collected after single neurological and ophthalmological evaluations. Dyschromatopsia was defined by the presence of at least 1 error using Hardy-Rand-Rittler plates. RESULTS: In our population of 125 patients, 79 patients (63.2%) never had ON and 35 (28.8%) had unilateral ON. The prevalence of dyschromatopsia in eyes of patients without ON was 25.7%. Patients with dyschromatopsia had a statistically significant lower RNFL thickness (P = 0.004 and P = 0.040, right and left eyes, respectively) and worse performance in symbol digit modalities test (P = 0.012). No differences were found in macular volume or motor function tasks. CONCLUSIONS: Dyschromatopsia occurs frequently in MS patients. It may be associated with a worse disease status and possibly serve as a marker for the detection of subclinical disease progression since it was detected even in the absence of ON. It correlated with thinner peripapillary RNFL thickness and inferior cognitive performance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Neuroophthalmol. 2016 Sep;36(3):275-9pt_PT
dc.identifier.doi10.1097/WNO.0000000000000401pt_PT
dc.identifier.issn1536-5166
dc.identifier.urihttp://hdl.handle.net/10400.10/1783
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott, Williams & Wilkinspt_PT
dc.subjectColor vision defectspt_PT
dc.subjectMultiple sclerosispt_PT
dc.subjectEsclerose múltiplapt_PT
dc.titleDyschromatopsia in Multiple Sclerosis Patients: A Marker of Subclinical Involvement?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceHagerstown, MDpt_PT
oaire.citation.endPage279pt_PT
oaire.citation.startPage275pt_PT
oaire.citation.titleJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Societypt_PT
oaire.citation.volume36pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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