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Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and Their Relation to Faecal Calprotectin Levels

dc.contributor.authorMagro, F
dc.contributor.authorLopes, J
dc.contributor.authorBorralho, P
dc.contributor.authorLopes, S
dc.contributor.authorCoelho, R
dc.contributor.authorCotter, J
dc.contributor.authorOliveira, A, et al.
dc.date.accessioned2019-12-11T14:23:22Z
dc.date.available2019-12-11T14:23:22Z
dc.date.issued2019
dc.description.abstractBackground and aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and the ability of faecal calprotectin [FC] levels to discriminate between these statuses. Methods: This was an analysis of three prospective cohorts including 422 patients previously enrolled in other studies. Results: The two continuous scores [GS and RHI] were shown to be significantly correlated [correlation coefficient of 0.806, p < 0.001] and particularly close regarding their definition of histological response: 95% and 88% of all patients classified as having/not having [respectively] histological response according to RHI also did so according to GS. Moreover, median FC levels in patients with histological response were lower than those in patients without histological response [GS: 73.00 vs 525.00, p < 0.001; RHI: 73.50 vs 510.00, p < 0.001]; a similar trend was observed when FC levels of patients in histological remission were compared to those of patients with histological activity [GS: 76.00 vs 228.00, p < 0.001; RHI: 73.50 vs 467.00, p < 0.001]. FC levels allowed us to exclude the absence of histological remission [according to RHI] and absence of histological response [according to RHI and GS], with negative predictive values varying from 82% to 96%. However, optimization of the FC cut-off to exclude the absence of histological remission, as for the continuous GS, falls within values that resemble those of the healthy population. Conclusion: The continuous GS and RHI histological scores are strongly correlated in their definitions of histological response. An absence of histological remission could only be excluded at physiological levels of FC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crohns Colitis 2019 Sep 4[Online ahead of print]pt_PT
dc.identifier.doi10.1093/ecco-jcc/jjz123pt_PT
dc.identifier.issn1876-4479
dc.identifier.urihttp://hdl.handle.net/10400.10/2344
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectUlcerative colitispt_PT
dc.subjectRemission inductionpt_PT
dc.titleComparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and Their Relation to Faecal Calprotectin Levelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceOxfordpt_PT
oaire.citation.titleJournal of Crohn's and Colitispt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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