Publication
Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and Their Relation to Faecal Calprotectin Levels
| dc.contributor.author | Magro, F | |
| dc.contributor.author | Lopes, J | |
| dc.contributor.author | Borralho, P | |
| dc.contributor.author | Lopes, S | |
| dc.contributor.author | Coelho, R | |
| dc.contributor.author | Cotter, J | |
| dc.contributor.author | Oliveira, A, et al. | |
| dc.date.accessioned | 2019-12-11T14:23:22Z | |
| dc.date.available | 2019-12-11T14:23:22Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Background and aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and the ability of faecal calprotectin [FC] levels to discriminate between these statuses. Methods: This was an analysis of three prospective cohorts including 422 patients previously enrolled in other studies. Results: The two continuous scores [GS and RHI] were shown to be significantly correlated [correlation coefficient of 0.806, p < 0.001] and particularly close regarding their definition of histological response: 95% and 88% of all patients classified as having/not having [respectively] histological response according to RHI also did so according to GS. Moreover, median FC levels in patients with histological response were lower than those in patients without histological response [GS: 73.00 vs 525.00, p < 0.001; RHI: 73.50 vs 510.00, p < 0.001]; a similar trend was observed when FC levels of patients in histological remission were compared to those of patients with histological activity [GS: 76.00 vs 228.00, p < 0.001; RHI: 73.50 vs 467.00, p < 0.001]. FC levels allowed us to exclude the absence of histological remission [according to RHI] and absence of histological response [according to RHI and GS], with negative predictive values varying from 82% to 96%. However, optimization of the FC cut-off to exclude the absence of histological remission, as for the continuous GS, falls within values that resemble those of the healthy population. Conclusion: The continuous GS and RHI histological scores are strongly correlated in their definitions of histological response. An absence of histological remission could only be excluded at physiological levels of FC. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Crohns Colitis 2019 Sep 4[Online ahead of print] | pt_PT |
| dc.identifier.doi | 10.1093/ecco-jcc/jjz123 | pt_PT |
| dc.identifier.issn | 1876-4479 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2344 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Oxford University Press | pt_PT |
| dc.subject | Biomarkers | pt_PT |
| dc.subject | Ulcerative colitis | pt_PT |
| dc.subject | Remission induction | pt_PT |
| dc.title | Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and Their Relation to Faecal Calprotectin Levels | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Oxford | pt_PT |
| oaire.citation.title | Journal of Crohn's and Colitis | pt_PT |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |