Publication
Prescrição de Anti-Inflamatórios Não Esteroides a Doentes com Diabetes Mellitus em Portugal
| dc.contributor.author | Vieira, M | |
| dc.contributor.author | Neves, JS | |
| dc.contributor.author | Baptista, R | |
| dc.contributor.author | Leitão, L | |
| dc.contributor.author | Dias, C | |
| dc.contributor.author | Vicente, R, et al. | |
| dc.date.accessioned | 2019-12-23T10:41:25Z | |
| dc.date.available | 2019-12-23T10:41:25Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | INTRODUCTION: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal. MATERIAL AND METHODS: We analyzed the national prescription database in triennium 2015 - 2017. In patients with diabetes mellitus, we evaluated the prescription of non-steroidal anti-inflammatory drugs according to age, gender and region of the patient and specialty of the prescribing physician. We evaluated the prescription of non-steroidal anti-inflammatory drugs in all patients with diabetes mellitus, in patients with presumed renal impairment, and in those with concomitant prescription of angiotensin converting enzyme inhibitors or angiotensin receptor antagonists. RESULTS: We analyzed 23 320 620 prescriptions, corresponding to 610 157 adults, including 104 306 patients with diabetes mellitus. The most prescribed non-steroidal anti-inflammatory drugs were ibuprofen (20.1%), metamizole (14.7%), and diclofenac (11.4%). The prescription of non-steroidal anti-inflammatory drugs was higher in females, in patients aged 51 - 70 years and in the Alentejo region. Non-steroidal anti-inflammatory drugs were prescribed to 70.6% of patients with diabetes mellitus, from which 10.6% were prescribed ≥ 10 packages during the three years. Among patients with diabetes mellitus on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and with presumed reduction in kidney function, 69.3% were prescribed non-steroidal anti-inflammatory drugs and 11.5% were prescribed ≥ 10 packages during the three years. DISCUSSION: The level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus is high. The concern of reducing non-steroidal anti-inflammatory drugs prescription to patients already on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and/or decreased renal function does not seem to exist. CONCLUSION: In Portugal, the level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus should be reduced, particularly in the subgroups identified with higher prescription and with higher risk of progression to stage 5 chronic kidney disease. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Acta Med Port. 2019 Feb 28;32(2):119-125 | pt_PT |
| dc.identifier.doi | 10.20344/amp.10815 | pt_PT |
| dc.identifier.issn | 1646-0758 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2372 | |
| dc.language.iso | por | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Centro Editor Livreiro da Ordem dos Médicos | pt_PT |
| dc.relation.publisherversion | file:///U:/Downloads/10815-42953-3-PB.pdf | pt_PT |
| dc.subject | Antagonistas de receptores de angiotensina | pt_PT |
| dc.subject | Diabetes mellitus | pt_PT |
| dc.subject | Inibidores da enzima conversora de angiotensina | pt_PT |
| dc.subject | Insuficiência renal crónica | pt_PT |
| dc.subject | Portugal | pt_PT |
| dc.title | Prescrição de Anti-Inflamatórios Não Esteroides a Doentes com Diabetes Mellitus em Portugal | pt_PT |
| dc.title.alternative | Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa | pt_PT |
| oaire.citation.title | Acta médica portuguesa | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |