Repository logo
 
Publication

The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTO-FFR) Study.

dc.contributor.authorLeone, A
dc.contributor.authorMartin-Reyes, R
dc.contributor.authorBaptista, SB
dc.contributor.authorAmabile, N
dc.contributor.authorRaposo, L
dc.contributor.authorFranco Pelaez, JA, et al.
dc.date.accessioned2019-02-14T15:52:45Z
dc.date.available2019-02-14T15:52:45Z
dc.date.issued2016
dc.description.abstractAIMS: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during submaximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). METHODS AND RESULTS: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93±0.05 vs. 0.87±0.08 vs. 0.84±0.08, p<0.001). A strong correlation and a close agreement at Bland-Altman analysis between cFFR and FFR were observed (r=0.90, p<0.001 and 95% CI of disagreement: from -0.042 to 0.11). ROC curve analysis showed an excellent accuracy (89%) of the cFFR cut-off of ≤0.85 in predicting an FFR value ≤0.80 (AUC 0.95 [95% CI: 0.94-0.96]), significantly better than that observed using resting Pd/Pa (AUC: 0.90, 95% CI: 0.88-0.91; p<0.001). A cFFR/FFR hybrid approach showed a significantly lower number of lesions requiring adenosine than a resting Pd/Pa/FFR hybrid approach (22% vs. 44%, p<0.0001). CONCLUSIONS: cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow limiting the use of adenosine to obtain FFR to a minority of stenoses with considerable savings of time and costs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuroIntervention. 2016 Aug 20;12(6):708-15pt_PT
dc.identifier.doi10.4244/EIJV12I6A115pt_PT
dc.identifier.issn1969-6213
dc.identifier.urihttp://hdl.handle.net/10400.10/2112
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociété Europa éditionpt_PT
dc.subjectContrast mediapt_PT
dc.subjectCoronary stenosispt_PT
dc.titleThe Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTO-FFR) Study.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceToulousept_PT
oaire.citation.endPage715pt_PT
oaire.citation.startPage708pt_PT
oaire.citation.titleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.pt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
(2016) MEMENTO Study (Eurointervention).pdf
Size:
1.07 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: