Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/292
Título: A short neuropsychologic and cognitive evaluation of frontotemporal dementia
Autor: Herrero Valverde, A
Jimenez-Escrig, A
Gobernado, J
Barón, M
Palavras-chave: Doença de Alzheimer
Alzheimer’s disease
Diagnóstico diferencial
Differential diagnosis
Data: 2009
Editora: Elsevier
Citação: Clin Neurol Neurosurg. 2009 Apr;111(3):251-5
Resumo: Objective: To elaborate a brief but efficient neuropsychological assessment of frontotemporal dementia (FTD), selecting the most specific and sensitive cognitive and behavioural items for distinguish between AD and FTD in the earlier dementia stages. Methods: Retrospective study with three groups, 35 patients with FTD, 46 with AD and 36 normal subjects, were administered the MMSE, FAB, Tower of London and Stoop’s test along with a 98 items behavioural and cognitive questionnaire. The most sensitive itemswere selected and validated internally for diagnosis by lineal discriminant analysis. Results: From the 98 items in the questionnaire, 29 showed significant discriminatory power. Noncognitive symptoms with higher odd-ratio for FTD compared to AD were impairment in social behaviour (disinhibition, aggressiveness), loss of insight and inappropriate acts. Language disorders, such as echolalia, verbal apraxia or aggramatism, dominate in the cognitive profile of FTD. FAB was confirmed as the best cognitive instrument to differentiate FTD and AD. A linear discriminant function with the combination of the FAB score and the items from our questionnaire with higher OR for FTD accurately classified 97% of individuals. Conclusions: The neuropsychological tests allow the differentiation between FTD and AD. The combination of FAB test with the assessment of key behavioural and cognitive symptoms appears helpful in this distinction.
Peer review: yes
URI: http://hdl.handle.net/10400.10/292
ISSN: 1872-6968
Aparece nas colecções:NEU - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Clin Neurol Neurosurg. 2009 Apr 111(3) 251-5. Epub 2008 Dec 4..pdf194,99 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.