Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/672
Título: Efavirenz concentrations in HIV-infected patients with and without viral hepatitis
Autor: Pereira, S
Caixas, U
Branco, T
Germano, I
Lampreia, F
Papoila, A
Monteiro, E
Palavras-chave: Infecção por HIV
Hepatite B
Hepatite C
HIV infections
Hepatitis B
Hepatitis C
Data: 2008
Editora: Wiley-Blackwell
Citação: Br J Clin Pharmacol. 2008 Oct;66(4):551-5
Resumo: AIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentrations over a 2-year follow-up period. RESULTS: No differences were found in efavirenz concentrations between groups both during and at the end of the follow-up period: control (2.43 +/- 1.91 mg l(-1)) vs. co-infected individuals (2.37 +/- 0.37 mg l(-1)). CONCLUSION: It was concluded that HBV/HCV infections in themselves do not predispose to an overexposure to efavirenz.
Peer review: yes
URI: http://hdl.handle.net/10400.10/672
ISSN: 0306-5251
Aparece nas colecções:INF - Artigos

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