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Infecciologia

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http://hdl.handle.net/10400.10/227

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Browsing Infecciologia by Subject "Amadora"

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  • HPV type-specific distribution in a group of women attending at Hospital Fernando Fonseca, Lisbon
    Publication . Santos, S; Pista, A; Pedro, A; Álvares, C; Ribeiro, C; Costa, C; Inácio, N; Pereira, S; Verdasca, N
    Introduction: Genital HPV infection is very frequent. Nevertheless, type-specific distribution can vary greatly in different populations. Aim: To assess the HPV frequency and type-specific distribution in a highly ethnically diverse region and its association with gynecological cytology. Material and Methods: From March to July 2009, 419 LBC samples (ThinPrep) were collected from women 16-79 years old, attending Hospital Fernando Fonseca and associated Primary Health Care Centers. HPV genotyping was performed using CLINICAL ARRAY HPV 2. Statistical analysis was performed (Chi-Square test). Results: Out of 419 women (median age: 41 years), 74.0% were Caucasian and 21.0% African. Overall, 90.2% of the women had a normal cytology, 4.3% had ASCUS, 3.1% LSIL, 1.7% HSIL, and 0.7% had invasive carcinoma. HPV infection was detected in 25.8% of the cases, whereas in 75.0% of women between 20-45 years. HR-HPV genotypes were identified in 57.8% of the infected women. The most frequent HR-HPV types were HPV16 (11.4%), HPV52 (8.5%), HPV31 and 58 (7.2% each). Multiple infections (2-6 genotypes) were observed in 34.2%. HPV58, 16, 31, and 52 (9.5%, 7.4%, 7.4%, 7.4%, respectively) were the most frequent genotypes. HPV DNA was detected in 19.6% of the women with normal cytology, of which 31.0% had multiple infections. In ASCUS, LSIL, HSIL and invasive carcinoma, HPV was detected in 66.7%, 100%, 100%, and 66.7%, respectively. HPV16, 31, 52, 58 and 42 were most frequent among Caucasian and HPV16, 83, 52, 53 and 54 among African women. HPV16 and 18 were found in 4.5% and 1.0% of the women. Infection by multiple HPV was related to lesion grade (p=0.042). Conclusion: Our results are consistent with the data observed in the literature. Our findings can help achieve a better understanding of the wide spectrum of HPV infection and can contribute to a baseline for future assessment of screening and immunization strategies.
    2010Conference object Open access Show more
  • Tipos de HPV num grupo de mulheres da área de influência do Hospital Fernando Fonseca, EPE, Amadora, Portugal
    Publication . Santos, S; Pista, A; Pedro, A; Álvares, C; Ribeiro, C; Costa, C; Inácio, N; Pereira, S; Verdasca, N
    2010Conference object Open access Show more