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Is there a proximal shift in the distribution of colorectal adenomas?

2015Journal article Open access
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dc.contributor.authorOliveira, AM
dc.contributor.authorAnapaz, V
dc.contributor.authorLourenço, L
dc.contributor.authorRodrigues, C
dc.contributor.authorAlberto, S
dc.contributor.authorMartins, A
dc.contributor.authorDeus, JR
dc.contributor.authorReis, J
dc.date.accessioned2016-03-29T15:55:38Z
dc.date.available2016-03-29T15:55:38Z
dc.date.issued2015
dc.description.abstractINTRODUCTION: Several studies have shown a proximal shift of colorectal cancer (CRC) during the last decades. However, few have analyzed the changing distribution of adenomas over time. AIM: The aim of this study was to compare the site and the characteristics of colorectal adenomas, in a single center, during two periods. METHODS: We conducted a retrospective, observational study in a single hospital of adenomas removed during a total colonoscopy in two one-year periods: 2003 (period 1) and 2012 (period 2). Patients with inflammatory bowel disease, familial adenomatous polyposis, hereditary non-polyposis colorectal cancer syndrome, or history of CRC were excluded from the study. The χ(2) statistical test was performed. P values less than 0.05 were considered statistically significant. RESULTS: During the two considered periods, a total of 864 adenomas from 2394 complete colonoscopies were analyzed: 333 adenomas from 998 colonoscopies during period 1 and 531 adenomas from 1396 colonoscopies during period 2. There was a significant increase in the proportion of adenomatous polyps in the proximal colon from period 1 to 2 (30.6% to 38.8% (p = 0.015)). Comparing the advanced features of adenomas between the two periods, it was noted that in period 2, the number of adenomas with size ≥1 cm (p = 0.001), high-grade dysplasia (p = 0.001), and villous features (p < 0.0001) had a significant increase compared to period 1. CONCLUSION: Incidence of adenomatous polyps in the proximal colon as well as adenomas with advanced features has increased in the last years. This finding may have important implications regarding methods of CRC screening.pt_PT
dc.identifier.citationUnited European Gastroenterol J. 2015 Aug;3(4):353-7pt_PT
dc.identifier.doi10.1177/2050640615577534pt_PT
dc.identifier.issn2050-6414
dc.identifier.urihttp://hdl.handle.net/10400.10/1597
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSage Publicationspt_PT
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528209/pdf/10.1177_2050640615577534.pdfpt_PT
dc.subjectColorectal neoplasmspt_PT
dc.subjectMass screeningpt_PT
dc.subjectNeoplasias colorrectaispt_PT
dc.subjectRastreiopt_PT
dc.titleIs there a proximal shift in the distribution of colorectal adenomas?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.endPage357pt_PT
oaire.citation.startPage353pt_PT
oaire.citation.titleUnited European gastroenterology journalpt_PT
oaire.citation.volume3pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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