Repository logo
 
Publication

Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis-the ACERTIVE study.

2017Journal article Open access
Simple item page
dc.contributor.authorMagro, F
dc.contributor.authorLopes, S
dc.contributor.authorCoelho, R
dc.contributor.authorCotter, J
dc.contributor.authorCastro, F
dc.contributor.authorSousa, H
dc.contributor.authorSalgado, M
dc.contributor.authorAndrade, P
dc.contributor.authorVieira, A
dc.contributor.authorFigueiredo, P
dc.contributor.authorCaldeira, P
dc.contributor.authorSousa, A
dc.contributor.authorDuarte, M
dc.contributor.authorÁvila, F
dc.contributor.authorSilva, J
dc.contributor.authorMoleiro, J
dc.contributor.authorMendes, S
dc.contributor.authorGiestas, S
dc.contributor.authorMinistro, P
dc.contributor.authorSousa, P
dc.contributor.authorGonçalves, R
dc.contributor.authorGonçalves, B
dc.contributor.authorOliveira, A
dc.contributor.authorChagas, C
dc.contributor.authorTorres, J
dc.contributor.authorDias, C
dc.contributor.authorLopes, J
dc.contributor.authorBorralho, P
dc.contributor.authorAfonso, J
dc.contributor.authorGeboes, K
dc.contributor.authorCarneiro, F
dc.contributor.authorPortuguese IBD Study Group [GEDII].
dc.date.accessioned2017-08-09T14:54:48Z
dc.date.available2017-08-09T14:54:48Z
dc.date.issued2017
dc.description.abstractBACKGROUND AND AIMS: Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin and neutrophil gelatinase B-associated lipocalin as biomarkers for disease activity in asymptomatic ulcerative colitis patients. METHODS: This was a multicentric cross-sectional study including 371 patients, who were classified according to their endoscopic and histological scores. These results were evaluated alongside the faecal levels of both biomarkers. RESULTS: Macroscopic lesions [i.e. endoscopic Mayo score ≥1] were present in 28% of the patients, and 9% had active disease according to fht Ulcerative Colitis Endoscopic Index of Severity. Moreover, 21% presented with histological inflammation according to the Geboes index, whereas 15% and 5% presented with focal and diffuse basal plasmacytosis, respectively. The faecal levels of calprotectin and neutrophil gelatinase B-associated lipocalin were statistically higher for patients with endoscopic lesions and histological activity. A receiver operating characteristic-based analysis revealed that both biomarkers were able to indicate mucosal healing and histological remission with an acceptable probability, and cut-off levels of 150-250 μg/g for faecal calprotectin and 12 μg/g for neutrophil gelatinase B-associated lipocalin were proposed. CONCLUSIONS: Faecal calprotectin and neutrophil gelatinase B-associated lipocalin levels are a valuable addition for assessment of disease activity in asymptomatic ulcerative colitis patients. Biological levels of the analysed biomarkers below the proposed thresholds can rule out the presence of macroscopic and microscopic lesions with a probability of 75-93%. However, caution should be applied whenever interpreting positive results, as these biomarkers present consistently low positive predictive values.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crohns Colitis. 2017 Apr 1;11(4):435-444pt_PT
dc.identifier.doi10.1093/ecco-jcc/jjw170pt_PT
dc.identifier.issn1876-4479
dc.identifier.urihttp://hdl.handle.net/10400.10/1922
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.subjectUlcerative colitispt_PT
dc.subjectColite ulcerosapt_PT
dc.subjectFecespt_PT
dc.subjectBiomarkerspt_PT
dc.subjectRemission inductionpt_PT
dc.subjectRemissão induzidapt_PT
dc.titleAccuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis-the ACERTIVE study.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceOxfordpt_PT
oaire.citation.endPage444pt_PT
oaire.citation.startPage435pt_PT
oaire.citation.titleJournal of Crohn's and Colitispt_PT
oaire.citation.volume11pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
J Crohns Colitis. 2017 Apr.pdf
Size:
1.77 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

GAS - Artigos publicados em revistas indexadas