Publication
Spreading of HIV-1 subtype G and envB/gagG recombinant strains among injecting drug users in Lisbon, Portugal.
| dc.contributor.author | Esteves, A | |
| dc.contributor.author | Parreira, R | |
| dc.contributor.author | Piedade, J | |
| dc.contributor.author | Venenno, T | |
| dc.contributor.author | Franco, M | |
| dc.contributor.author | Sousa, JG | |
| dc.contributor.author | Patrício, L | |
| dc.contributor.author | Brum, P | |
| dc.contributor.author | Costa, A | |
| dc.contributor.author | Canas-Ferreira, W | |
| dc.date.accessioned | 2013-01-08T15:16:01Z | |
| dc.date.available | 2013-01-08T15:16:01Z | |
| dc.date.issued | 2003 | |
| dc.description.abstract | We have evaluated the genetic diversity of HIV-1 strains infecting injecting drug users (IDUs) in Lisbon, Portugal. Heteroduplex mobility assay and/or phylogenetic analysis revealed that env (C2V3C3 or gp41) subtype B is present in 63.7% of the 135 viral samples studied, followed by subtypes G (23.7%), A (6.7%), F (5.2%), and D (0.7%). Similar analysis of gag (p24/p7) performed on 91 of the specimens demonstrated that 49.5% of the infections were caused by subtype G viruses; other gag subtypes identified were B (39.5%), F (3.3%), A and D (1.1.% each), and the recombinant circulating form CRF02_AG (5.5%). Discordant env/gag sub-types were detected in 34.1% of the strains and may reflect the presence of dual infections and/or recombinant viruses. The presumptive B/G recombinant form was highly predominant (21 of 31). The genetic pattern of HIV-1 subtype B and G strains is suggestive of multiple introductions and recombination episodes and of a longstanding presence of both subtypes in the country. C2V3C3 amino acid sequences from IDU-derived subtype G viruses presented highly significant signatures, which distinguish the variants from this transmission group. The unusually high prevalence of subtype G sequences (34.1%), independent of the geographic origin of the infected individuals, makes this IDU HIV-1 epidemic unique. | por |
| dc.identifier.citation | AIDS Res Hum Retroviruses. 2003 Jun;19(6):511-7 | por |
| dc.identifier.issn | 1931-8405 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/845 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Mary Ann Liebert | por |
| dc.subject | HIV infections | por |
| dc.subject | Substance Abuse | por |
| dc.subject | Epidemiology | por |
| dc.subject | Portugal | por |
| dc.title | Spreading of HIV-1 subtype G and envB/gagG recombinant strains among injecting drug users in Lisbon, Portugal. | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | New York | por |
| oaire.citation.endPage | 517 | por |
| oaire.citation.startPage | 511 | por |
| oaire.citation.title | AIDS Research and Human Retroviruses | por |
| oaire.citation.volume | 19 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |