Venous thromboprophylaxis duration and adherence to international guidelines in patients undergoing major orthopaedic surgery: Results of the international, longitudinal, observational DEIMOS registry.

Arcelus, J; Felicíssimo, P; DEIMOS Investigators

http://hdl.handle.net/10400.10/966

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Thromb Res. 2013 Jun;131(6) e240-6.pdf		332.46 KB	Adobe PDF	Download

Send Feedback

Authors

Arcelus, J

Felicíssimo, P

DEIMOS Investigators

Abstract(s)

BACKGROUND: Venous thromboembolism (VTE) is major health problem worldwide with substantial morbidity and mortality. This study aimed to assess post-operative VTE prophylaxis duration and adherence to the American College of Chest Physicians (ACCP) 2008 guidelines in patients having undergone major orthopaedic surgery (MOS). METHODS: This multinational, longitudinal, observational registry recruited consecutive patients (≥18years of age) who underwent total hip replacement (THR), total knee replacement (TKR), and hip fracture surgery (HFS). There were 3 study visits: at admission to hospital, at discharge, and 4/6weeks after surgery. Data on demographics, medical history, VTE risk factors, type and duration of mechanical and pharmacological prophylaxis, complications, and adherence to the ACCP 2008 guidelines were collected using case report forms. RESULTS: Between October 2009 and July 2011, 2162 eligible patients were analyzed: THR: 646, TKR: 740, HFS: 776 (mean age [SD]: 64.5 [15.0] years; female: 61.3%; and mean hospitalization duration [SD]: 9.1 [8.2] days). VTE prophylaxis was prescribed to 96.2% of patients during hospitalization and 89.7% of patients after hospital discharge. Prophylaxis was prescribed according to the ACCP 2008 guidelines in 85.7% of patients during hospitalization and 63.4% of patients after hospital discharge. The main reasons for non-adherence to guidelines were no prescription and inadequate duration of prophylaxis. The low molecular weight heparin-enoxaparin-was the most commonly prescribed prophylaxis. CONCLUSION: We observed a gap between real life VTE prophylaxis and the ACCP 2008 recommendations. Improved prescription of extended thromboprophylaxis is warranted to ensure adherence to international guidelines.