Repository logo
 
Publication

Sterile leukocyturia is associated with interstitial fibrosis and tubular atrophy in kidney allograft protocol biopsies.

dc.contributor.authorCoelho, S
dc.contributor.authorOrtiz, F
dc.contributor.authorGelpir, R
dc.contributor.authorKoskinen, P
dc.contributor.authorPorta, N
dc.contributor.authorBestard, O
dc.contributor.authorMelilli, E
dc.contributor.authorTaco, O
dc.contributor.authorTorras, J
dc.contributor.authorHonkanen, E
dc.contributor.authorGrinyó, J
dc.contributor.authorCruzado, J
dc.date.accessioned2015-08-26T15:29:44Z
dc.date.available2015-08-26T15:29:44Z
dc.date.issued2014
dc.description.abstractKidney allograft interstitial fibrosis and tubular atrophy (IF/TA) is associated with a poorer renal function and outcome. In the current clinical practice, an early diagnosis can only be provided by invasive tests. We aimed to investigate the association of sterile leukocyturia with Banff criteria histological findings in kidney allograft protocol biopsies. We studied 348 allograft biopsies from two different European countries performed at 8.5 + 3.5 months after transplantation. In these cases, the presence of sterile leukocyturia (Leuc+, n = 70) or no leukocyturia (Leuc-, n = 278) was analyzed and related to Banff elementary lesions. Only IF/TA was significantly different between Leuc+ and Leuc- groups. IF/TA was present in 85.7% of Leuc+ and 27.7% of Leuc- patients (p < 0.001). IF/TA patients had higher serum creatinine and presence of proteinuria (p < 0.05). Independent predictors of IF/TA were donor age, donor male sex, serum creatinine and Leuc+ (hazard ratio 18.2; 95% confidence interval, 8.1-40.7). The positive predictive value of leukocyturia for predicting IF/TA was 85.7% whereas the negative predictive value was 72.3%. These studies suggest that leukocyturia is a noninvasive and low-cost test to identify IF/TA. An early diagnosis may allow timely interventional measures directed to minimize its impact and improve graft outcomepor
dc.identifier.citationAm J Transplant. 2014 Apr;14(4):908-15por
dc.identifier.doi10.1111/ajt.12639
dc.identifier.urihttp://hdl.handle.net/10400.10/1519
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherthe American Society of Transplantation and the American Society of Transplant Surgeons.por
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/ajt.12639/epdfpor
dc.subjectKidney diseasespor
dc.subjectAtrophypor
dc.subjectFibrosispor
dc.subjectBiological markerspor
dc.subjectLeukocytespor
dc.subjectKidney transplantationpor
dc.titleSterile leukocyturia is associated with interstitial fibrosis and tubular atrophy in kidney allograft protocol biopsies.por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceHobokenpor
oaire.citation.endPage915por
oaire.citation.startPage908por
oaire.citation.titleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeonspor
oaire.citation.volume14por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Am J Transplant. 2014 Apr,14(4) 908-15.pdf
Size:
275.81 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: