Publication
C-reactive protein may influence decisively the prescription of prophylactic antibiotics in acute pancreatitis: a population-based cohort study
| dc.contributor.author | Cardoso, F | |
| dc.contributor.author | Ricardo, L | |
| dc.contributor.author | Gondar, P | |
| dc.contributor.author | Deus, JR | |
| dc.contributor.author | Horta, D | |
| dc.date.accessioned | 2019-05-23T13:54:25Z | |
| dc.date.available | 2019-05-23T13:54:25Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | OBJECTIVES: Prescription of prophylactic antibiotics in acute pancreatitis (AP) is controversial. We aimed to identify the patients' characteristics that may prompt clinicians to prescribe prophylactic antibiotics in AP. METHODS: This single-center retrospective cohort study included 299 consecutive patients with AP from a Portuguese hospital in 2009 to 2010. Logistic regression was used to study the association of patients' characteristics with prescription of prophylactic antibiotics in AP. RESULTS: Persistent organ failure developed in 7% of patients (9/136). The median C-reactive protein at 48 hours after hospital admission was 154 mg/L (interquartile range, 55-271 mg/L). Bedside Index for Severity in AP score greater than or equal to 3 occurred in 14% of patients (42/299). Pancreatic necrosis was diagnosed in 21% of the patients (35/169). Computerized Tomography Severity Index score greater than 3 occurred in 23% of patients (38/169). In-hospital mortality rate was 4% (10/299). Prophylactic antibiotics were prescribed to 14% of patients (42/299). After adjusting for persistent organ failure and Computerized Tomography Severity Index score greater than 3, C-reactive protein at 48 hours after hospital admission greater than or equal to 150 mg/L was significantly associated with higher likelihood of receiving prophylactic antibiotics (odds ratio, 12.2). Prophylactic antibiotics did not improve in-hospital mortality rate (P = 0.637). CONCLUSIONS: C-reactive protein was the most influential in prescribing prophylactic antibiotics in AP. Clinicians may need better tools to support the decision to prescribe prophylactic antibiotics in AP. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Pancreas. 2015 Apr;44(3):404-8 | pt_PT |
| dc.identifier.doi | 10.1097/MPA.0000000000000279 | pt_PT |
| dc.identifier.issn | 1536-4828 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2269 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Lippincott Williams & Wilkins | pt_PT |
| dc.subject | Acute pancreatitis | pt_PT |
| dc.subject | Acute disease | pt_PT |
| dc.subject | C-reactive protein | pt_PT |
| dc.title | C-reactive protein may influence decisively the prescription of prophylactic antibiotics in acute pancreatitis: a population-based cohort study | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Hagerstown, MD | pt_PT |
| oaire.citation.title | Pancreas | pt_PT |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |