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An 18-year-old woman with a 34-cm metaplastic breast carcinoma

dc.contributor.authorGomes, A
dc.contributor.authorSantos, V
dc.contributor.authorDias, G
dc.contributor.authorManso, RT
dc.contributor.authorGonçalves, L
dc.contributor.authorCoiteiro, M
dc.contributor.authorGaspar, H
dc.contributor.authorNazaré, A
dc.date.accessioned2015-04-22T15:22:01Z
dc.date.available2015-04-22T15:22:01Z
dc.date.issued2015
dc.description.abstractMetaplastic breast carcinomas (MBCs) are rare malignancies usually with poor prognosis. We report a case of an 18-year-old African female patient who presented with a 34-cm tumor on the right breast. Biopsy showed an extensively necrotic MBC negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (triple negative). A modified right radical mastectomy was performed, followed by adjuvant chemotherapy. Histology confirmed a widely necrotic undifferentiated malignant tumor, with strong and diffuse expression of vimentin and B-cell lymphoma 2, focal high-molecular-weight keratins and focal CD34 expression; Ki67 was >90%. There was no skin, deep margin or lymph node involvement. Six months after surgery, the patient showed a 9 × 7 cm nodule adjacent to the suture and adherent to the anterior chest wall. The tumor was considered unresectable and the patient evolved with rapid systemic deterioration. The patient had a progression-free survival of 6 months and overall survival of 9 months.por
dc.identifier.citationJ Surg Case Rep. 2015 Jan;1: 1-4por
dc.identifier.doi10.1093/jscr/rju141.
dc.identifier.urihttp://hdl.handle.net/10400.10/1416
dc.language.isoporpor
dc.peerreviewedyespor
dc.publisherOxford University Presspor
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294453/pdf/rju141.pdfpor
dc.subjectBreast neoplasmspor
dc.subjectMastectomypor
dc.subjectPrognosispor
dc.titleAn 18-year-old woman with a 34-cm metaplastic breast carcinomapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceOxfordpor
oaire.citation.endPage4por
oaire.citation.startPage1por
oaire.citation.titleJournal of surgical case reportspor
oaire.citation.volume1por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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