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Senile Systemic Amyloidosis: An Underdiagnosed Disease.

dc.contributor.authorManso, M
dc.contributor.authorMarques, D
dc.contributor.authorRocha, S
dc.contributor.authorRodeia, S
dc.contributor.authorDomingos, R
dc.date.accessioned2019-02-22T14:16:00Z
dc.date.available2019-02-22T14:16:00Z
dc.date.issued2017
dc.description.abstractSenile systemic amyloidosis is caused by a non-mutated form of transthyretin with the heart being the major organ involved. This infiltrative cardiomyopathy usually presents as slowly progressive heart failure. An 82-year-old female patient was admitted for newly diagnosed heart failure. A year later she presented with decompensated heart failure and syncope. Inpatient work-up showed persistently elevated troponin and N-terminal-pro BNP levels, rapid progression to severe left ventricular concentric hypertrophy, and sinus pauses on the Holter. Cardiac MRI revealed diffuse late gadolinium enhancement in the left ventricle. The demonstration of amyloid protein with the clinical findings and complementary investigations allowed for the diagnosis of senile systemic amyloidosis. LEARNING POINTS: Senile systemic amyloidosis is a rare disease with a common clinical presentation that is probably underdiagnosed in patients with heart failure with preserved systolic function.A new unexplained heart failure diagnosis, increased ventricular wall thickness and particularly low voltage on the ECG should raise the suspicion of cardiac amyloidosis.Histopathological evidence of amyloid deposition elsewhere and typical advanced imaging features can support the diagnosis, rendering endomyocardial biopsy no longer mandatory.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Case Rep Intern Med. 2017 Sep 21;4(9):000725pt_PT
dc.identifier.doi10.12890/2017_000725pt_PT
dc.identifier.issn2284-2594
dc.identifier.urihttp://hdl.handle.net/10400.10/2136
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSMC Mediapt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346851/pdf/725-1-4082-1-10-20170920.pdfpt_PT
dc.subjectAmyloidosispt_PT
dc.subjectHeart failurept_PT
dc.titleSenile Systemic Amyloidosis: An Underdiagnosed Disease.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceMilanopt_PT
oaire.citation.titleEuropean Journal of Case Reports in Internal Medicinept_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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