Publication
Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain
| dc.contributor.author | Rebelo-de-Andrade, H | |
| dc.contributor.author | Pereira, C | |
| dc.contributor.author | Gíria, M | |
| dc.contributor.author | Prudêncio, E | |
| dc.contributor.author | Brito, MJ | |
| dc.contributor.author | Calé, E | |
| dc.contributor.author | Taveira, N | |
| dc.date.accessioned | 2011-08-30T14:14:13Z | |
| dc.date.available | 2011-08-30T14:14:13Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most (96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7/3). Both the AdV3 and the AdV7/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential. | por |
| dc.identifier.citation | J Clin Microbiol. 2010 Apr;48(4):1391-6 | por |
| dc.identifier.issn | 0095-1137 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/415 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Society for Microbiology | por |
| dc.subject | Infecções por adenovirus | por |
| dc.subject | Criança | por |
| dc.subject | Adenovirus humano | por |
| dc.subject | Infecções respiratórias | por |
| dc.subject | Portugal | por |
| dc.subject | Respiratory infection | por |
| dc.subject | Human adenovirus | por |
| dc.title | Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Washington | por |
| oaire.citation.endPage | 1396 | por |
| oaire.citation.startPage | 1391 | por |
| oaire.citation.title | Journal of Clinical Microbiology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
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