Publication
Atrioventricular block related to liposomal amphotericin B
| dc.contributor.author | Sanches, B | |
| dc.contributor.author | Nunes, P | |
| dc.contributor.author | Almeida, H | |
| dc.contributor.author | Rebelo, M | |
| dc.date.accessioned | 2019-06-21T14:30:18Z | |
| dc.date.available | 2019-06-21T14:30:18Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Atrioventricular block can occur in normal children, young adults or athletes. It is also associated with underlying heart disease or occurs as a drug adverse effect. Amphotericin B is used in the treatment of invasive fungal infections. Cardiac toxicity is a rare adverse reaction. We report the case of a 9-month girl, admitted in the paediatric intensive care unit with cytomegalovirus pneumonitis. During hospitalisation the patient developed a systemic fungic infection and was medicated with liposomal amphotericin B. On the third day of treatment she began repeated episodes of bradycardia with spontaneous reversion. The investigation revealed a second-degree atrioventricular block. We excluded the misplacement of the central catheter, myocarditis or structural cardiomyopathy and suspended amphotericin. After 8 days, the bradycardia episodes ceased what was consistent with the drug's half-life. Amphotericin cardiotoxic mechanism is still unclear. It may be related with alteration of myocardial membrane depolarisation. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | BMJ Case Rep. 2014 Jun 6;2014. pii: bcr2013202688. | pt_PT |
| dc.identifier.doi | 10.1136/bcr-2013-202688 | pt_PT |
| dc.identifier.issn | 1757-790X | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/2296 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | BMJ Pub. Group | pt_PT |
| dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054472/pdf/bcr-2013-202688.pdf | pt_PT |
| dc.subject | Atrioventricular block | pt_PT |
| dc.subject | Amphotericin B | pt_PT |
| dc.subject | Antifungal agents | pt_PT |
| dc.subject | Cardiotoxicity | pt_PT |
| dc.title | Atrioventricular block related to liposomal amphotericin B | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | London | pt_PT |
| oaire.citation.title | BMJ case reports. | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |