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Publication
Atypical renal presentation of antiphospholipid syndrome
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Advisor(s)
Abstract(s)
Antiphospholipid syndrome (APS) is a systemic autoimmune disease which can occur as a primary disease or in
association with other autoimmune diseases, the most frequent being Systemic Lupus Erythematosus (SLE). Although
renal manifestations of SLE are well known, antiphospholipid syndrome renal manifestations such as antiphospholipid syndrome nephropathy and glomerulopathies have yet to be better characterized. The authors present the
case of a 39 -year -old Caucasian woman with antiphospholipid syndrome diagnosis and a previous history of deep
venous thrombosis and intermittent polyarthralgia, who was referred to a nephrology consultation for proteinuria
and microscopic haematuria with preserved renal function. The renal biopsy showed a pattern of membranous
glomerulopathy and thrombotic microangiopathy in association with antiphospholipid syndrome nephropathy.
This case report illustrates a complex clinical and anatomopathological case of a 39 - year -old woman with a
previous antiphospholipid syndrome diagnosis who presented with unspecific manifestations such as proteinuria
and microscopic haematuria and preserved renal function. The histological findings alert us to the range of possible renal manifestations of APS and the need to better characterize these patients by preforming renal biopsy.
Description
Keywords
Antiphospholipid syndrome Renal biopsy
Citation
Port J Nephrol Hypert 2017; 31(3): 217-220
Publisher
Sociedade Portuguesa de Nefrologia