Repository logo
 
Publication

Cytomegalovirus (CMV) and transfusion therapy: prevalence of cmv seropositivity in a portuguese blood donor population (2007-2014)

2015Conference object Open access
Simple item page
dc.contributor.authorCardoso, E
dc.contributor.authorLichtner, A
dc.contributor.authorBarra, A
dc.contributor.authorCosta, C
dc.contributor.authorPlácido, C
dc.contributor.authorNunes, C
dc.contributor.authorFerreira, M
dc.contributor.authorRebelo, S
dc.contributor.authorSantos, C
dc.contributor.authorMota, M
dc.date.accessioned2017-03-27T13:39:35Z
dc.date.available2017-03-27T13:39:35Z
dc.date.issued2015
dc.descriptionVox Sanguinis (2015) 109 (Suppl.1), 204pt_PT
dc.description.abstractBackground: Cytomegalovirus (CMV or human herpesvisrus-5) is a common infection and not clinically significant in immunocompetent individuals. It’s the most important herpesvirus with reference to transfusion and, as all human herpesvirus, has the capability to lie dormant in tissues after an acute infection. The risk of CMV infectivity is still a major problem in immunocompromised patients requiring transfusion therapy, and should be minimized in CMV-negative pregnant women, fetuses, premature infants and neonats, transplant recipients and other severely immunosuppressed patients. The residual risk of transfusion-transmitted CMV infection is between 2.3% and 3% for leucocyte-reduced blood components, and the additional use of anti-CMV screened blood components decreases this risk to less than 1%, which, in our point of view, justifies the non-abandonment of CMV-seronegative blood bank inventories, especially in high prevalent populations. There is substantial variation in the donor rates of CMV seropositivity described in the literature (20-95%) and it seems to be inversely related to improved hygiene and living conditions. The same principle applies to the seroconversion rate per year. Aims: To determine the prevalence of CMV seropositivity and CMV seroconversion rate per year in a Portuguese blood donor population over an eight-year period of time (2007-2014), and compare it to those mentioned in other studies. Methods: Blood samples from donors were analyzed during the period 2007-2014 (8 years), and tested for detection of anti-CMV antibodies (‘total’ anti-CMV ELISA-based assays, capable of detecting both IgG and IgM class antibodies- Siemens Enzygnost® Anti-CMV/IgG+IgM), as they belonged to a first-time or to a previously tested CMV-seronegative donor. The prevalence of CMV seropositivity and the seroconversion rate per year were retrospectively determined among this blood donors population. Results: A total of 42.286 blood collections were analyzed. The prevalence of CMV infection was determined for each year: 2007 – 86.4%; 2008 – 87,2%; 2009 – 86.5%; 2010 – 88.9%; 2011 – 90.2%; 2012 – 89.7%; 2013 – 91,3%; 2014 – 89,4%. The CMV seroconversion rate per year was 1.43% (average age of seroconversion 36.4 years old; 81.8% men and 18,2% women). Summary/Conclusions: All blood components transfused in Portugal are leucocyte-reduced. We try to provide CMV seronegative blood components to all patients in high risk CMV infection, even in a high prevalent population as ours. The existence of CMV-seronegative blood bank inventories does not reflect practice countrywide, but is still important for some high-risk groups of patients, and allows us to respond to the needs of our hospital and other institutions (whenever possible).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationREGIONAL CONGRESS OF THE ISBT, 25, London, June 27-July 1, 2015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.10/1828
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInternational Society of Blood Transfusionpt_PT
dc.subjectTransfusão de sanguept_PT
dc.subjectDadores de sanguept_PT
dc.subjectInfecções por citomegaloviruspt_PT
dc.subjectPortugalpt_PT
dc.titleCytomegalovirus (CMV) and transfusion therapy: prevalence of cmv seropositivity in a portuguese blood donor population (2007-2014)pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.titleREGIONAL CONGRESS OF THE ISBTpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Poster_CMV_Transfusion Therapy_Prevalence_CMV Seropositivity_Portuguese Blood Donor Population_2007-2014_ISBT_London_2015.pdf
Size:
3.58 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

IMU - Comunicações e Conferências