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Granular cell tumor of the breast: correlations between imaging and pathology findings

2020Journal article Open access
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dc.contributor.authorAbreu, N
dc.contributor.authorFilipe, J
dc.contributor.authorAndré, S
dc.contributor.authorMarques, JC
dc.date.accessioned2020-07-01T11:38:15Z
dc.date.available2020-07-01T11:38:15Z
dc.date.issued2020
dc.description.abstractOBJECTIVE: To review the imaging features of granular cell tumors of the breast (on mammography, ultrasound, and magnetic resonance imaging), establishing a pathological correlation, in order to familiarize radiologists with this entity and make them aware of the differential diagnoses, other than malignancy, of lesions with spiculated margins. MATERIALS AND METHODS: We reviewed the medical records (from a clinical-pathology database and picture archiving and communication system) of five patients with a pathologically confirmed diagnosis of granular cell tumor of the breast, treated at the Portuguese Oncology Institute of Lisbon, in the city of Lisbon, Portugal, between January 2012 and December 2018. RESULTS: All five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions), namely spiculated margins, significant depth, and posterior acoustic shadowing (on ultrasound). One tumor showed a kinetic curve indicative of washout on magnetic resonance imaging, two were adherent to the pectoralis muscle, and one was accompanied by skin retraction. Pathology provided the definitive diagnosis in all cases. CONCLUSION: Granular cell tumors of the breast pose a diagnostic challenge because they can present with clinical and imaging features mimicking malignancy, and the diagnosis is therefore provided by pathology. Radiologists should be familiarized with this entity, so they can be aware of the fact that breast lesions with spiculated margins can be indicative of diagnoses other than malignancy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRadiol Bras. 2020 Mar-Apr;53(2):105-111pt_PT
dc.identifier.doi10.1590/0100-3984.2019.0056pt_PT
dc.identifier.issn1678-7099
dc.identifier.urihttp://hdl.handle.net/10400.10/2432
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherColegio Brasileiro De Radiologiapt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170582/pdf/rb-53-02-0105.pdfpt_PT
dc.subjectBreast neoplasmspt_PT
dc.subjectGranular cell tumorpt_PT
dc.subjectMammographypt_PT
dc.subjectUltrasonographypt_PT
dc.subjectMagnetic resonance imagingpt_PT
dc.titleGranular cell tumor of the breast: correlations between imaging and pathology findingspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceRio de Janeiropt_PT
oaire.citation.titleRadiologia Brasileirapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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