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Examining the motor phenotype of patients with both essential tremor and Parkinson's disease.

2012Journal article Open access
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dc.contributor.authorSimões, R
dc.contributor.authorConstantino, A
dc.contributor.authorGibadullina, E
dc.contributor.authorHoughton, D
dc.contributor.authorLouis, E
dc.contributor.authorLitvan, I
dc.date.accessioned2012-08-10T13:55:02Z
dc.date.available2012-08-10T13:55:02Z
dc.date.issued2012
dc.description.abstractPrevious reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor-predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor-dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD.por
dc.identifier.citationTremor Other Hyperkinet Mov (N Y). 2012;2. pii: 47por
dc.identifier.issn2160-8288
dc.identifier.urihttp://hdl.handle.net/10400.10/649
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherCenter for Digital Research and Scholarshippor
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379814/?tool=pubmedpor
dc.subjectDoença de Parkinsonpor
dc.subjectTremorpor
dc.subjectAvaliação da incapacidadepor
dc.subjectParkinson’s diseasepor
dc.subjectEssential tremorpor
dc.subjectSeverity of illness indexpor
dc.titleExamining the motor phenotype of patients with both essential tremor and Parkinson's disease.por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Yorkpor
oaire.citation.titleTremor and Other Hyperkinetic Movementspor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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