Publication
Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli.
| dc.contributor.author | Manageiro, V | |
| dc.contributor.author | Félix, D | |
| dc.contributor.author | Jones-Dias, D | |
| dc.contributor.author | Sampaio, D | |
| dc.contributor.author | Vieira, L | |
| dc.contributor.author | Sancho, L | |
| dc.contributor.author | Ferreira, E | |
| dc.contributor.author | Caniça, M | |
| dc.date.accessioned | 2018-04-16T15:49:53Z | |
| dc.date.available | 2018-04-16T15:49:53Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Front Microbiol. 2017 Oct 9;8:1899 | pt_PT |
| dc.identifier.doi | 10.3389/fmicb.2017.01899 | pt_PT |
| dc.identifier.issn | 1664-302X | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/1996 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Frontiers Research Foundation | pt_PT |
| dc.subject | Escherichia coli | pt_PT |
| dc.subject | QepA4 gene variant | pt_PT |
| dc.title | Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli. | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lausanne | pt_PT |
| oaire.citation.title | Frontiers in Microbiology | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |