From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries.

Damoiseaux, J; Agmon-Levin, N; Van Blerk, M; Sousa, MJ, et al.

http://hdl.handle.net/10400.10/1205

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Clin Exp Rheumatol. 2014 Jun 30. [Epub ahead of print].pdf		943.23 KB	Adobe PDF	Download

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Abstract(s)

OBJECTIVES: One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD). METHODS: A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries. RESULTS: The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries. CONCLUSIONS: Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.