Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.10/1993
Title: Psoriasis-associated vascular disease: the role of HDL.
Author: Paiva-Lopes, MJ
Alves, J
Keywords: Cardiovascular diseases
Psoriasis
HDL lipoproteins
Issue Date: 2017
Publisher: BioMed Central
Citation: J Biomed Sci. 2017 Sep 14;24(1)
Abstract: Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2-3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiovascular disease is the most frequent cause of death in patients with severe psoriasis. Several cardiovascular disease classical risk factors are also increased in psoriasis but the psoriasis-associated risk persists after adjusting for other risk factors.Investigation has focused on finding explanations for these epidemiological data. Several studies have demonstrated significant lipid metabolism and HDL composition and function alterations in psoriatic patients. Altered HDL function is clearly one of the mechanisms involved, as these particles are of the utmost importance in atherosclerosis defense. Recent data indicate that biologic therapy can reverse both structural and functional HDL alterations in psoriasis, reinforcing their therapeutic potential.
Peer review: yes
URI: http://hdl.handle.net/10400.10/1993
DOI: 10.1186/s12929-017-0382-4
ISSN: 1423-0127
Publisher Version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598036/pdf/12929_2017_Article_382.pdf
Appears in Collections:MED - Artigos

Files in This Item:
File Description SizeFormat 
12929_2017_Article_382.pdf459,98 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.