Browsing by Author "Mendes, J"
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- Alterações do pH no diagnostico das intoxicaçõesPublication . Jonet, M; Mendes, J; Freitas, PT
- Cefaleias tipo tensão: perspetiva psiquiátricaPublication . Mendes, J; Ribeiro, LIntrodução: As cefaleias tipo tensão (Ctt) são as mais frequentes na população em geral e aquelas com maior impacto socioeconómico no universo das cefaleias, tendo em conta o elevado grau de incapacidade que provocam. Objectivo: Os autores propõem‑se a realizar uma revisão da literatura disponível acerca deste tema, numa perspetiva psiquiátrica. Discussão: Diversos estudos têm identificado uma maior prevalência de perturbações psiquiátricas, traços de personalidade e mecanismos de coping pouco eficazes em doentes com Ctt, pelo que, é fundamental compreender esta relação e o impacto dos fatores psicopatológicos nestas cefaleias. Conclusão: A sua abordagem clínica e terapêutica é dificultada por estes e outros fatores e nelas têm sido utilizadas múltiplas estratégias de tratamento farmacológico e psico‑comportamental, no entanto, a evidência científica é, ainda, escassa.
- Polymicrobial interactions influence the agr copy number in Staphylococcus aureus isolates from diabetic foot ulcersPublication . Matias, C; Serrano, I; Van-Harten, S; Mottola, C; Mendes, J; Tavares, L; Oliveira, MDiabetic foot ulcers are a major complication of diabetes and are often colonised by complex bacterial communities, where Staphylococcus aureus is frequently co-present with Pseudomonas aeruginosa. These bacteria interact through quorum sensing, encoded in S. aureus by the accessory gene regulator (agr). Typing and copy number of S. aureus agr were assessed here to give insights on strain variability and possible interspecies influence. As agr is classified in four genetic groups, agr-I, agr-II, agr-III and agr-IV, the agr type of 23 S. aureus diabetic foot ulcers isolates was evaluated by PCR and gene copy number determined by qPCR, including in S. aureus present in polymicrobial infections. agr-I and agr-II were found to be present in 52 and 39% of the isolates, respectively. In two isolates, no agr type was identified, and types III and IV were not detected. Interestingly, agr-II copy number was higher in dual suspensions than in S. aureus single suspension. We conclude that agr type I was the most frequent in clinical centers in Lisbon, and variations in agr-I and agr-II copy numbers were strain specific. Variations in agr copy number in dual suspensions suggests that P. aeruginosa may influence S. aureus agr-II gene regulation, confirming an interaction between these two bacteria. This is a first approach to characterise agr variation in S. aureus from diabetic foot ulcers in vitro.
- Sociedade Portuguesa de Cuidados Intensivos guidelines for stress ulcer prophylaxis in the intensive care unit.Publication . Mendes, J; Silva, MJ; Miguel, L; Gonçalves, MA; Oliveira, MJ; Oliveira, C; Gouveia, JCritically ill patients are at risk of developing stress ulcers in the upper digestive tract. Agents that suppress gastric acid are commonly prescribed to reduce the incidence of clinically important stress ulcer-related gastrointestinal bleeding. However, the indiscriminate use of stress ulcer prophylaxis in all patients admitted to the intensive care unit is not warranted and can have potential adverse clinical effects and cost implications. The present guidelines from the Sociedade Portuguesa de Cuidados Intensivos summarizes the current evidence and gives six clinical statements and an algorithm aiming to provide a standardized prescribing policy for the use of stress ulcer prophylaxis in the intensive care unit.