Browsing by Author "Nogueira, F"
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- Diferença tensional entre os membros superiores: um estudo em mulheres grávidasPublication . Veríssimo, C; Matos, T; Rocha, I; Nogueira, FAim: To ascertain the prevalence of inter-arm blood pressure difference in excess of 10 mmHg in pregnant women. Population: A total of 114 pregnant women selected at random from those admitted to our Maternal and Fetal Medicine Unit. Design: Prospective, descriptive study. Methods: Blood pressure was measured on both arms twice (same operator, method and equipment). Other variants analysed were maternal age, admission diagnosis, gestational age, weight, parity, heart rate, ethnicity, handedness and pulse pressure. Results: Mean age was 26.9 years with a standard deviation (sd) of 6.2; Most women were admitted for labour induction (37%) or because of hypertensive disorders of pregnancy (18%). Mean gestational age was 34.1 weeks (sd=6.9) . Right arm blood pressure was on average 121.4 (sd=20.4) over 74.6 (sd=13.8) mmHg. Mean left arm blood pressure was 121.2 (sd=20.1) over 74.7 (sd=13.4). Mean interarm blood pressure differences were 5.2 (sd=4.5) mmHg during systole and 3.3 (sd=3.3) during diastole. Results were not significantly different in hypertensive women. Differences exceeding 10 mmHg were found in 14.0% of women Correlations between inter-arm blood pressure differences exceeding 10 mmHg and age, gestational age, weight, and parity were weak. Conclusions: It is not possible to recommend one arm in which to measure blood pressure. A possible strategy is to evaluate both arms at the first clinical appointment, and to follow-up with the arm showing the highest BP.
- Esforço multidisciplinar para a evicção de um surto de parotidite epidémica numa maternidadePublication . Veríssimo, C; Matos, T; Matos, F; Rocha, I; Nogueira, FMumps is a disease caused by paramyxovirus, whose notification to health authorities is mandatory. Vaccination in Portugal was started in 1987. There have been several outbreaks worldwide, even in populations with high vaccination rates, but none were reported in maternity hospitals. We report the case of a 36 year-old primigravida, admitted in the 37th week of pregnancy, because of fever, painful uterine contractions and a non-reassuring cardiotocograph. A caesarean section was performed 28 hours after admission due to non-reassuring fetal status, and a newborn with normal Apgar score was delivered. The following day she developed headache, tender bilateral parotid swelling, effacement of the mandibular angle, and tender cervical limphadenopathies. The patient was isolated, and blood samples were collected for paramyxovirus’ serology. All her contacts (healthcare providers and puerperas) were clinically evaluated and non-immunized subjects were vaccinated. Relatives were contacted and counselled. Primary healthcare facilities were asked to facilitate access to the vaccination unit. The Neonatology Department was alerted and the newborn’s blood was sampled for serologic testing. Public authorities were notified through an appropriate declaration form. The patient progressively recovered. Disease was serologically confirmed in the newborn but was asymptomatic. Healthcare providers, contacted puerperas and their newborns were followed up for 4 weeks but none developed symptoms
- Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs.Publication . Escobar, C; Pateira, S; Lobo, E; Lobo, L; Teodósio, R; Dias, F; Fernandes, N; Arez, AP; Varandas, L; Nogueira, FWe report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed. A total of three different mutations (R471R and R575R in Angola and V494I in Mozambique) were identified in five samples, all collected after the introduction of ACT. The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon). However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported. V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.