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Publication
Adenocarcinomas nasossinusais: experiência do Serviço de Otorrinolaringologia do Instituto Português de Oncologia de Lisboa entre 2000 e 2014
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Advisor(s)
Abstract(s)
Objetivos: Analisar dados demográficos, apresentação clínica,
fatores de risco, opções terapêuticas e sobrevida de doentes
com adenocarcinoma nasossinusal.
Material e Métodos: Estudo retrospetivo de doentes com
Adenocarcinoma Nasossinusal tratados entre 2000 e 2014, no IPOFGL.
Resultados: Identificamos 33 doentes com diagnóstico
de Adenocarcinoma. A idade média foi de 65.6 anos. A
terapêutica mais comum foi cirurgia com radioterapia
adjuvante. A sobrevida global e livre de doença aos 3 anos foi
de 57.6% e 40.5%. A invasão do seio esfenoidal (p=0.038) e
da base do crânio (p=0.003) influenciaram a sobrevida global.
O desenvolvimento de metástases à distância teve impacto
sobre a sobrevida livre de doença (p=0.01).
Conclusões: Os Adenocarcinomas são tumores raros. A excisão
da lesão toma um papel determinante no tratamento dos
doentes. Na nossa amostra, a invasão do seio esfenoidal, da
base do crânio e o desenvolvimento de metástases à distância
estão associados a um pior prognóstico.
Objective: To analyze treatment outcomes, including overall and disease-free survival rates, of patients with sinonasal adenocarcinomas. Methods: Retrospective study of patients with sinonasal adenocarcinoma treated in IPOFGL between 2000 and 2014. Results: We identified 33 patients; 17 were women and 16 men. Average age at diagnosis was 65.6 years and median follow-up was 39 months. Ethmoid sinus was the most frequent location; 51% presented at AJCC stage IV. Surgery with adjuvant radiotherapy was used in 70%. Overall survival at 36 months was 57.6%, with 40.5% disease-free survival. Recurrence was caused by local failure in majority of cases. Survival was decreased significantly in patients with sphenoid sinus involvement (p=0.038), skull base invasion (p=0.003) and recurrence metastatic disease (p<0.05). Conclusions: Complete surgical removal with postoperative radiotherapy remains the standard treatment modality. Sphenoid sinus and skull base invasion, and development of distant metastasis portend for poor prognosis.
Objective: To analyze treatment outcomes, including overall and disease-free survival rates, of patients with sinonasal adenocarcinomas. Methods: Retrospective study of patients with sinonasal adenocarcinoma treated in IPOFGL between 2000 and 2014. Results: We identified 33 patients; 17 were women and 16 men. Average age at diagnosis was 65.6 years and median follow-up was 39 months. Ethmoid sinus was the most frequent location; 51% presented at AJCC stage IV. Surgery with adjuvant radiotherapy was used in 70%. Overall survival at 36 months was 57.6%, with 40.5% disease-free survival. Recurrence was caused by local failure in majority of cases. Survival was decreased significantly in patients with sphenoid sinus involvement (p=0.038), skull base invasion (p=0.003) and recurrence metastatic disease (p<0.05). Conclusions: Complete surgical removal with postoperative radiotherapy remains the standard treatment modality. Sphenoid sinus and skull base invasion, and development of distant metastasis portend for poor prognosis.
Description
Keywords
Neoplasias da cabeça e pescoço Neoplasias dos seios perinasais Adenocarcinoma
Citation
Rev Port Otorrinol Cirur Cerv Fac. 2015;54(1):39-45
Publisher
Sociedade Portuguesa de Otorrinolaringologia e Cirurgia Cérvico-Facial