Repository logo
 
Publication

Adenocarcinomas nasossinusais: experiência do Serviço de Otorrinolaringologia do Instituto Português de Oncologia de Lisboa entre 2000 e 2014

2016Journal article Open access
Simple item page
dc.contributor.authorMoura, I
dc.contributor.authorAnjo, C
dc.contributor.authorColaço, J
dc.contributor.authorCarvalho, T
dc.contributor.authorPacheco, R
dc.contributor.authorMontalvão, P
dc.contributor.authorMagalhães, M
dc.date.accessioned2016-05-25T14:36:35Z
dc.date.available2016-05-25T14:36:35Z
dc.date.issued2016
dc.description.abstractObjetivos: Analisar dados demográficos, apresentação clínica, fatores de risco, opções terapêuticas e sobrevida de doentes com adenocarcinoma nasossinusal. Material e Métodos: Estudo retrospetivo de doentes com Adenocarcinoma Nasossinusal tratados entre 2000 e 2014, no IPOFGL. Resultados: Identificamos 33 doentes com diagnóstico de Adenocarcinoma. A idade média foi de 65.6 anos. A terapêutica mais comum foi cirurgia com radioterapia adjuvante. A sobrevida global e livre de doença aos 3 anos foi de 57.6% e 40.5%. A invasão do seio esfenoidal (p=0.038) e da base do crânio (p=0.003) influenciaram a sobrevida global. O desenvolvimento de metástases à distância teve impacto sobre a sobrevida livre de doença (p=0.01). Conclusões: Os Adenocarcinomas são tumores raros. A excisão da lesão toma um papel determinante no tratamento dos doentes. Na nossa amostra, a invasão do seio esfenoidal, da base do crânio e o desenvolvimento de metástases à distância estão associados a um pior prognóstico.pt_PT
dc.description.abstractObjective: To analyze treatment outcomes, including overall and disease-free survival rates, of patients with sinonasal adenocarcinomas. Methods: Retrospective study of patients with sinonasal adenocarcinoma treated in IPOFGL between 2000 and 2014. Results: We identified 33 patients; 17 were women and 16 men. Average age at diagnosis was 65.6 years and median follow-up was 39 months. Ethmoid sinus was the most frequent location; 51% presented at AJCC stage IV. Surgery with adjuvant radiotherapy was used in 70%. Overall survival at 36 months was 57.6%, with 40.5% disease-free survival. Recurrence was caused by local failure in majority of cases. Survival was decreased significantly in patients with sphenoid sinus involvement (p=0.038), skull base invasion (p=0.003) and recurrence metastatic disease (p<0.05). Conclusions: Complete surgical removal with postoperative radiotherapy remains the standard treatment modality. Sphenoid sinus and skull base invasion, and development of distant metastasis portend for poor prognosis.pt_PT
dc.identifier.citationRev Port Otorrinol Cirur Cerv Fac. 2015;54(1):39-45pt_PT
dc.identifier.issn0873-3864
dc.identifier.urihttp://hdl.handle.net/10400.10/1662
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Otorrinolaringologia e Cirurgia Cérvico-Facialpt_PT
dc.relation.publisherversionfile://u_share/users/arminda.m.sustelo/Downloads/330-1423-1-PB.pdfpt_PT
dc.subjectNeoplasias da cabeça e pescoçopt_PT
dc.subjectNeoplasias dos seios perinasaispt_PT
dc.subjectAdenocarcinomapt_PT
dc.titleAdenocarcinomas nasossinusais: experiência do Serviço de Otorrinolaringologia do Instituto Português de Oncologia de Lisboa entre 2000 e 2014pt_PT
dc.title.alternativeSinonasal adenocarcinomas: experience of Lisbon Oncology Institute between 2000 and 2014pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
oaire.citation.endPage45pt_PT
oaire.citation.startPage39pt_PT
oaire.citation.titleRevista Portuguesa de Otorrinolaringologia e Cirurgia Cervico-Facialpt_PT
oaire.citation.volume54pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rev Port Otorrinol Cirur Cerv Fac. 2015,54(1)39-45.pdf
Size:
258.63 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ORL - Artigos publicados em revistas não indexadas