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Pregnancy with anti-PP1Pk antibody managed with prednisolone and low-molecular-weight heparin – A case report and literature review
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Orientador(es)
Resumo(s)
The anti-PP1Pk is a rare antibody associated with recurrent miscarriages, mainly in the first half of pregnancy.
There seems to be a direct correlation between the antibody titer and risk of miscarriage. As this is a rare entity,
few case reports have been published. The most frequently proposed therapeutic approaches are doublefiltration plasmapheresis and plasma exchange therapy. The rationale behind them is to remove the cytotoxic
antibodies from maternal circulation. Here, we present the case of a 30-year-old woman with a history of two
spontaneous miscarriages and a pre-conception anti-PP1Pk antibody titer of 1:4. As soon as she became pregnant, she was placed on prednisolone and low-molecular-weight heparin (LMWH). Biweekly antibody titers
were performed throughout the entire gestation and remained below 1:16. As the titers were considered to be
low, plasmapheresis was not performed. The pregnancy was uneventful and she delivered a healthy newborn
child at 37 weeks of gestation, with no signs of anaemia.
Descrição
Palavras-chave
Low-molecular-weight heparin Prednisolone Pregnancy
Contexto Educativo
Citação
Case Reports in Women's Health 27 (2020) e00238
Editora
Elsevier