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Pregnancy with anti-PP1Pk antibody managed with prednisolone and low-molecular-weight heparin – A case report and literature review

2020Journal article Open access
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dc.contributor.authorNascimento, S
dc.contributor.authorRodrigues, M
dc.contributor.authorHenriques, M
dc.contributor.authorDuarte, FP
dc.contributor.authorBarra, A
dc.contributor.authorMatos, T
dc.date.accessioned2020-07-06T10:26:15Z
dc.date.available2020-07-06T10:26:15Z
dc.date.issued2020
dc.description.abstractThe anti-PP1Pk is a rare antibody associated with recurrent miscarriages, mainly in the first half of pregnancy. There seems to be a direct correlation between the antibody titer and risk of miscarriage. As this is a rare entity, few case reports have been published. The most frequently proposed therapeutic approaches are doublefiltration plasmapheresis and plasma exchange therapy. The rationale behind them is to remove the cytotoxic antibodies from maternal circulation. Here, we present the case of a 30-year-old woman with a history of two spontaneous miscarriages and a pre-conception anti-PP1Pk antibody titer of 1:4. As soon as she became pregnant, she was placed on prednisolone and low-molecular-weight heparin (LMWH). Biweekly antibody titers were performed throughout the entire gestation and remained below 1:16. As the titers were considered to be low, plasmapheresis was not performed. The pregnancy was uneventful and she delivered a healthy newborn child at 37 weeks of gestation, with no signs of anaemia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCase Reports in Women's Health 27 (2020) e00238pt_PT
dc.identifier.doi10.1016/j.crwh.2020.e00238pt_PT
dc.identifier.issn2214-9112
dc.identifier.urihttp://hdl.handle.net/10400.10/2452
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionfile:///U:/Desktop/Case%20Reports%20in%20Women's%20Health.pdfpt_PT
dc.subjectLow-molecular-weight heparinpt_PT
dc.subjectPrednisolonept_PT
dc.subjectPregnancypt_PT
dc.titlePregnancy with anti-PP1Pk antibody managed with prednisolone and low-molecular-weight heparin – A case report and literature reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceAmsterdampt_PT
oaire.citation.titleCase Reports in Women's Healthpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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