Publication
Use of sedatives and neuromuscular blockers in a cohort of patients receiving mechanical ventilation.
| dc.contributor.author | Arroliga, A | |
| dc.contributor.author | Frutos-Vivar, F | |
| dc.contributor.author | Hall, J | |
| dc.contributor.author | Esteban, A | |
| dc.contributor.author | Apezteguía, C | |
| dc.contributor.author | Soto, L | |
| dc.contributor.author | Anzueto, A | |
| dc.contributor.author | Freitas, PT | |
| dc.contributor.author | International Mechanical Ventilation Study Group. | |
| dc.date.accessioned | 2012-08-29T13:00:24Z | |
| dc.date.available | 2012-08-29T13:00:24Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | OBJECTIVE: To describe the use of sedatives and neuromuscular blocking agents (NMBs) and their impact in outcome in an international cohort of patients receiving mechanical ventilation. METHODS: We analyzed the database of a prospective, multicenter cohort of 5,183 adult patients who received mechanical ventilation for > 12 h. We considered that a patient received a given agent when it was administered for at least 3 h in a 24-h period. RESULTS: A total of 3,540 patients (68%; 95% confidence interval [CI], 67 to 69%) received a sedative at any time while receiving mechanical ventilation. The median number of days of use was 3 (interquartile range [IQR], 2 to 6 days). The persistent use of sedative was associated with more days of mechanical ventilation (median, 4 days [IQR, 2 to 8 days], vs 3 days [IQR, 2 to 4 days] in patients who did not receive sedatives [p < 0.001]); more weaning days (median, 2 days [IQR, 1 to 3 days], vs 2 days [IQR, 1 to 5 days] in patients who did not receive sedatives [p < 0.001]); and longer length of stay in the ICU (median, 8 days [IQR, 5 to 15 days], vs 5 days [IQR, 3 to 9 days] in patients who did not receive sedatives [p < 0.001]). Six hundred eighty-six patients (13%; 95% CI, 12 to 14%) received an NMB for at least 1 day. The median number of days of use was 2 (IQR, 1 to 4 days). The administration of an NMB was independently related with age, a normal previous functional status, main reason of mechanical ventilation (patients with ARDS received more NMBs), and with patient management (patients requiring permissive hypercapnia, prone position, high level of positive end-expiratory pressure, and high airways pressure). CONCLUSIONS: The use of sedatives is very common, and their use is associated with a longer duration of mechanical ventilation, weaning time, and stay in the ICU. NMBs are used in 13% of the patients and are associated with longer duration of mechanical ventilation, weaning time, stay in the ICU, and higher mortality. | por |
| dc.identifier.citation | Chest. 2005 Aug;128(2):496-506. | por |
| dc.identifier.issn | 0012-3692 | |
| dc.identifier.uri | http://hdl.handle.net/10400.10/678 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | por |
| dc.publisher | American College of Chest Physicians | por |
| dc.subject | Respiração artificial | por |
| dc.subject | Unidade de cuidados intensivos | por |
| dc.subject | Mechanical ventilation | por |
| dc.subject | Intensive care units | por |
| dc.subject | Sedatives | por |
| dc.title | Use of sedatives and neuromuscular blockers in a cohort of patients receiving mechanical ventilation. | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Northbrook, IL | por |
| oaire.citation.endPage | 506 | por |
| oaire.citation.startPage | 496 | por |
| oaire.citation.title | Chest | por |
| oaire.citation.volume | 128 | por |
| rcaap.rights | openAccess | |
| rcaap.type | article | por |