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Behaviour of human erythrocyte aggregation in presence of autologous lipoproteins

2012Journal article Open access
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dc.contributor.authorSaldanha, C
dc.contributor.authorLoureiro, J
dc.contributor.authorMoreira, C
dc.contributor.authorSilva, J
dc.date.accessioned2014-02-28T16:40:39Z
dc.date.available2014-02-28T16:40:39Z
dc.date.issued2012
dc.description.abstractThe aim of this work was to evaluate in vitro the effect of autologous plasma lipoprotein subfractions on erythrocyte tendency to aggregate. Aliquots of human blood samples were enriched or not (control) with their own HDL-C, LDL-C, or VLDL-C fractions obtained from the same batch by density gradient ultracentrifugation. Plasma osmolality and erythrocyte aggregation index (EAI) were determined. Blood aliquots enriched with LDL-C and HDL-C showed significant higher EAI than untreated aliquots, whereas enrichment with VLDL-C does not induce significant EAI changes. For the same range of lipoprotein concentrations expressed as percentage of osmolality variation, the EAI variation was positive and higher in presence of HDL-C than upon enrichment with LDL-C (P < 0.01). Particle size, up to LDL diameter values, seems to reinforce erythrocyte tendency to aggregate at the same plasma osmolality (particle number) range of values.por
dc.identifier.citationBiochem Res Int. 2012;2012:261736. doi: 10.1155/2012/261736.por
dc.identifier.issn2090-2255
dc.identifier.urihttp://hdl.handle.net/10400.10/1086
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHindawi Pubpor
dc.relation.publisherversionhttp://www.hindawi.com/journals/bri/2012/261736/por
dc.subjectErythrocyte aggregationpor
dc.subjectAgregação eritrocíticapor
dc.subjectLipoproteinspor
dc.subjectLipoproteínaspor
dc.titleBehaviour of human erythrocyte aggregation in presence of autologous lipoproteinspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Yorkpor
oaire.citation.titleBiochemistry Research Internationalpor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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