Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.10/1996
Título: Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli.
Autor: Manageiro, V
Félix, D
Jones-Dias, D
Sampaio, D
Vieira, L
Sancho, L
Ferreira, E
Caniça, M
Palavras-chave: Escherichia coli
QepA4 gene variant
Data: 2017
Editora: Frontiers Research Foundation
Citação: Front Microbiol. 2017 Oct 9;8:1899
Resumo: A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.
Peer review: yes
URI: http://hdl.handle.net/10400.10/1996
DOI: 10.3389/fmicb.2017.01899
ISSN: 1664-302X
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