Browsing by Author "Campos, P"
Now showing 1 - 9 of 9
Results Per Page
Sort Options
- Avaliação morfológica e funcional por ecografia e doppler como fator preditivo da permeabilidade aos 12 meses em acessos vasculares proximais.Publication . Gomes, A; Germano, A; Sousa, M; Rocha, R; Marinho, R; Campos, P; Fragoso, M; Pignatelli, N; Nunes, VIntrodução: O mapeamento vascular por ecografia e doppler é crucial no planeamento de um acesso vascular para hemodiálise. O objectivo deste estudo é avaliar quais das variáveis anatómicas e hemodinâmicas arteriais e venosas, medidas por ecografia e Doppler, se associam a permeabilidade global aos 12 meses nos acessos vasculares proximais. Material e Métodos: Estudo observacional, analítico, longitudinal, com colheita retrospetiva de dados. Foram incluídos os doentes admitidos no nosso hospital entre Janeiro de 2011 e Junho de 2013 para a criação de acesso vascular proximal para hemodiálise como primeiro acesso, com mapeamento vascular por ecografia e doppler. Foram comparados os doentes com permeabilidade de acesso aos 12 meses com os doentes com falência de acesso até aos 12 meses. Foi feita análise univariada e multivariada. Foi utilizada estatística não paramétrica com significância para α=0,05. Resultados: Foram incluídos 61 doentes com idade média de 66,5±13,5 anos, 26 do sexo feminino, 18 fístulas umerobasílicas, 65,6% de permeabilidade global aos 12 meses. O diâmetro da artéria umeral (AU), o diâmetro da veia, o índice de resistência e a distensibilidade venosa não foram diferentes entre os grupos. O fluxo da AU (0,19l/min±0,11 vs 0,16l/min±0,06; U=215,0; df=59; p<0,05), a velocidade picosistólica da AU (78,77m/s±23,20 vs 65,47m/s±18,47; U=210,2; df=59; p<0,05) e a distância entre a artéria e a veia (31,73±11,9mm vs 17,75±8,61mm U=101,0; df=59; p<0,05) associaram-se a permeabilidade global aos 12 meses. A Diabetes Mellitus tipo II (DMII) foi mais prevalente entre os doentes com falência aos 12 meses (p<0,05). O diâmetro da AU correlacionou-se positivamente com o débito e a velocidade picosistólica da AU. A distensibilidade da veia correlacionou-se negativamente com o seu diâmetro sem garrote. Na análise por regressão logística, apenas a DMII demonstrou significância estatística, associando-se negativamente com permeabilidade aos 12 meses. Conclusões: Nos doentes estudados, o fluxo arterial, a velocidade picosistólica e a distância entre artéria e veia são superiores entre os doentes com permeabilidade global aos 12 meses quando comparados com os doente com falência de acesso. A DMII mostrou ser um factor de risco independente para falência de acesso aos 12 meses.
- Diálogo entre a glândula supra-renal e o rim na regulação do potássio: da fisiologia à fisiopatologiaPublication . Lima, A; Campos, P; Pires, A
- Doença renal crónica: relação com a flora intestinal e impacto da alimentaçãoPublication . Campos, P; Pires, A
- HIV and kidney diseases: 35 years of history and consequences.Publication . Campos, P; Ortiz, A; Soto, KKidney diseases in human immunodeficiency virus (HIV)-infected patients are often misdiagnosed. Despite reductions in morbidity and mortality owing to widespread use of highly effective combination antiretroviral therapy (cART), acute kidney injury (AKI) and chronic kidney disease (CKD) are still more common in these patients than in the general population, and are associated with poor health outcomes. HIV-associated nephropathy and HIV immune complex kidney diseases are the more recognizable HIV-related kidney diseases. However, a broad spectrum of kidney disorders related or not directly related with HIV infection can be observed, including cART-induced AKI, CKD, proximal tubular dysfunction, crystalluria and urolithiasis, among others. This review summarizes the major epidemiologic studies of kidney diseases in HIV-infected patients, discusses novel approaches that may potentially limit nephrotoxicity such as the use of tenofovir alafenamide, and outlines current screening measures for early diagnosis of kidney dysfunction or tubular damage, and for accurate detection of increased risk for acute or chronic kidney diseases.
- Nefrotoxicidade e lesão renal agudaPublication . Campos, P; Pires, A; Inchaustegui, L
- Severe Acute Kidney Injury and Double Tubulopathy Due to Dual Toxicity Caused by Combination Antiretroviral Therapy.Publication . Soto, K; Campos, P; Manso, RT, et al.
- Severe Systemic Lupus Erythematosus presentation in patient with alternative complement pathway mutationsPublication . Pereira, F; Cunha, L; Campos, P; Gaspar, A; Manso, RT; Soto, KSystemic lupus erythematosus (SLE) is an autoimmune disease which can involve almost any organ, making its difficult therapeutic approach. Immune complex deposition can often activate complement, accounting for many of SLE clinical manifestations and laboratory findings. We present a case of a patient who presented with acute pancreatitis and acute kidney injury as onset manifestations of SLE, later developing neurological manifestations, who was successfully treated with rituximab, plasma exchange and steroids as induction therapy. Persistently low C3 level led to a genetic analysis of the complement system components. We found three polymorphisms in the alternative pathway of complement regulators (complement factor H c2669 G>T, p.Ser890Ile and c3019 G>T, p.Val1007Leu and complement factor I c.482+6 G>T), two of which have been correlated with atypical haemolytic uraemic syndrome and dense deposit disease and also complement factor H -related protein (CFHR1 and CFHR3) mutations by deletion. This raises the question whether these polymorphisms and mutations played any role in our patient’s clinical course.
- Terapêutica diurética e mecanismos de resistência diuréticaPublication . Campos, P
- The risk of chronic kidney disease and mortality are increased after community-acquired acute kidney injury.Publication . Soto, K; Campos, P; Pinto, I; Rodrigues, B; Frade, F; Papoila, AL; Devarajan, PWe investigated whether community-acquired acute kidney injury encountered in a tertiary hospital emergency department setting increases the risk of chronic kidney disease (CKD) and mortality, and whether plasma biomarkers could improve the prediction of those adverse outcomes. In a prospective cohort study, we enrolled 616 patients at admission to the emergency department and followed them for a median of 62.1 months. Within this cohort, 130 patients were adjudicated as having acute kidney injury, 159 transient azotemia, 15 stable CKD, and 312 normal renal function. Serum cystatin C and plasma neutrophil gelatinase-associated lipocalin (NGAL) were measured at index admission. After adjusting for clinical variables, the risk of developing CKD stage 3, as well as the risk of death, were increased in the acute kidney injury group (hazard ratio [HR], 5.7 [95% confidence interval, 3.8-8.7] and HR, 1.9 [95% confidence interval, 1.3-2.8], respectively). The addition of serum cystatin C increased the ability to predict the risk of developing CKD stage 3, and death (HR, 1.5 [1.1-2.0] and 1.6 [1.1-2.3], respectively). The addition of plasma NGAL resulted in no improvement in predicting CKD stage 3 or mortality (HR, 1.0 [0.7-1.5] and 1.2 [0.8-1.8], respectively). The risk of developing CKD stage 3 was also significantly increased in the transient azotemia group (HR, 2.4 [1.5-3.6]). Thus, an episode of community acquired acute kidney injury markedly increases the risk of CKD, and moderately increases the risk of death. Our findings highlight the importance of follow-up of patients with community acquired acute kidney injury, for potential early initiation of renal protective strategies.