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Browsing by Author "Dias, G"

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  • An 18-year-old woman with a 34-cm metaplastic breast carcinoma
    Publication . Gomes, A; Santos, V; Dias, G; Manso, RT; Gonçalves, L; Coiteiro, M; Gaspar, H; Nazaré, A
    Metaplastic breast carcinomas (MBCs) are rare malignancies usually with poor prognosis. We report a case of an 18-year-old African female patient who presented with a 34-cm tumor on the right breast. Biopsy showed an extensively necrotic MBC negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (triple negative). A modified right radical mastectomy was performed, followed by adjuvant chemotherapy. Histology confirmed a widely necrotic undifferentiated malignant tumor, with strong and diffuse expression of vimentin and B-cell lymphoma 2, focal high-molecular-weight keratins and focal CD34 expression; Ki67 was >90%. There was no skin, deep margin or lymph node involvement. Six months after surgery, the patient showed a 9 × 7 cm nodule adjacent to the suture and adherent to the anterior chest wall. The tumor was considered unresectable and the patient evolved with rapid systemic deterioration. The patient had a progression-free survival of 6 months and overall survival of 9 months.
    2015Journal article Open access Show more
  • Anti-NMDA encephalitis and ovarian teratoma
    Publication . Dias, G; Mendinhos, G; Igreja, F; Pereira, JS
    Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis may be associated with ovarian teratoma and results in a characteristic syndrome that presents with psychiatric symptoms, rapid decline of the level of consciousness, central hypoventilation and seizures. Immunotherapy and resection of teratoma are effective therapies.
    2015Journal article Open access Show more
  • A case of follicular variant of papillary thyroid carcinoma in a mature cystic teratoma in a young woman
    Publication . Dias, G; Caeiro, F; Costa, T; Pedro, A; Pereira, JS
    Malignant transformation of a teratoma occurs in 1-2% of cases, with carcinoma of the thyroid being extremely rare. It is usually diagnosed in the postoperative histopathological exam. We describe a case of thyroid carcinoma in a mature cystic teratoma.
    2015Journal article Unknown Show more
  • Ectopia cordis: a case report
    Publication . Dias, G; Santos, AV; Martins, C; Ferreira, AP; Fonseca, J
    Introduction: ectopia cordis is a rare congenital malformation, with an estimated incidence of 5 to 8 per million live births. It is defined as a malformation in which the heart is located in an extra-thoracic position. Ectopia cordis may occur as an isolated malformation or associated with other anomalies such as omphalocele, congenital heart disease or integrating Cantrell syndrome. The size and location of the defect influence the prognosis. Description: we report a case of a 24-year-old nulliparous woman, with no relevant family or personal history, in which the prenatal fetal ultrasound, performed at 21 weeks of gestation, revealed a defect of the anterior chest wall with exteriorization of the heart. Discussion: fetal echocardiography revealed a severe congenital heart disease. The parents decided to continue the pregnancy, after being duly informed by a multidisciplinary team. Delivery occurred at 37 weeks of gestation but the female newborn died one hour afterwards. Pathological examination confirmed the sonographic findings.
    2014Journal article Unknown Show more
  • Incompetência cervico -ístmica
    Publication . Landim, E; Dias, G; Santos, V; Nazaré, A
    2011Conference object Unknown Show more